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Literature DB >> 32391416

Mapping the breakome reveals tight regulation on oncogenic super-enhancers.

Abstract

DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling mechanism between transcription and DNA repair at super-enhancers, as means of hypertranscription of oncogenic drivers.

Entities: Chemical Disease

Keywords: BLISS; DSBs; RAD51; breakome; super-enhancer

Year: 2020 PMID： 32391416 PMCID： PMC7199745 DOI： 10.1080/23723556.2019.1698933

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

9 in total

Review 1. DNA topoisomerase II and its growing repertoire of biological functions.

Authors: John L Nitiss
Journal: Nat Rev Cancer Date: 2009-04-20 Impact factor: 60.716

2. Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

Authors: Marc R Mansour; Brian J Abraham; Lars Anders; Alla Berezovskaya; Alejandro Gutierrez; Adam D Durbin; Julia Etchin; Lee Lawton; Stephen E Sallan; Lewis B Silverman; Mignon L Loh; Stephen P Hunger; Takaomi Sanda; Richard A Young; A Thomas Look
Journal: Science Date: 2014-11-13 Impact factor: 47.728

3. Genome Organization Drives Chromosome Fragility.

Authors: Andres Canela; Yaakov Maman; Seolkyoung Jung; Nancy Wong; Elsa Callen; Amanda Day; Kyong-Rim Kieffer-Kwon; Aleksandra Pekowska; Hongliang Zhang; Suhas S P Rao; Su-Chen Huang; Peter J Mckinnon; Peter D Aplan; Yves Pommier; Erez Lieberman Aiden; Rafael Casellas; André Nussenzweig
Journal: Cell Date: 2017-07-20 Impact factor: 41.582

Review 4. Endogenous DNA Damage as a Source of Genomic Instability in Cancer.

Authors: Anthony Tubbs; André Nussenzweig
Journal: Cell Date: 2017-02-09 Impact factor: 41.582

5. Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Authors: Warren A Whyte; David A Orlando; Denes Hnisz; Brian J Abraham; Charles Y Lin; Michael H Kagey; Peter B Rahl; Tong Ihn Lee; Richard A Young
Journal: Cell Date: 2013-04-11 Impact factor: 41.582

6. BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks.

Authors: Winston X Yan; Reza Mirzazadeh; Silvano Garnerone; David Scott; Martin W Schneider; Tomasz Kallas; Joaquin Custodio; Erik Wernersson; Yinqing Li; Linyi Gao; Yana Federova; Bernd Zetsche; Feng Zhang; Magda Bienko; Nicola Crosetto
Journal: Nat Commun Date: 2017-05-12 Impact factor: 14.919

7. Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51.

Authors: Idit Hazan; Jonathan Monin; Britta A M Bouwman; Nicola Crosetto; Rami I Aqeilan
Journal: Cell Rep Date: 2019-10-15 Impact factor: 9.423

8. Transcriptional elongation requires DNA break-induced signalling.

Authors: Heeyoun Bunch; Brian P Lawney; Yu-Fen Lin; Aroumougame Asaithamby; Ayesha Murshid; Yaoyu E Wang; Benjamin P C Chen; Stuart K Calderwood
Journal: Nat Commun Date: 2015-12-16 Impact factor: 14.919

9. Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.

Authors: François Aymard; Beatrix Bugler; Christine K Schmidt; Emmanuelle Guillou; Pierre Caron; Sébastien Briois; Jason S Iacovoni; Virginie Daburon; Kyle M Miller; Stephen P Jackson; Gaëlle Legube
Journal: Nat Struct Mol Biol Date: 2014-03-23 Impact factor: 18.361

9 in total

2 in total

Review 1. Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States.

Authors: Sara Oster; Rami I Aqeilan
Journal: Cells Date: 2020-08-10 Impact factor: 6.600

Review 2. Targeting DNA Damage Response in Prostate and Breast Cancer.

Authors: Antje M Wengner; Arne Scholz; Bernard Haendler
Journal: Int J Mol Sci Date: 2020-11-04 Impact factor: 5.923

2 in total