Tillmann Wallborn1,2, Mandy Vogel3, Antje Kneuer4, Michael Thamm4, Katalin Dittrich5, Wieland Kiess5,3, Jürgen Kratzsch6. 1. University Hospital for Children and Adolescents, University of Leipzig, 04103, Leipzig, Germany. tillwallborn@gmail.com. 2. LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. tillwallborn@gmail.com. 3. LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. 4. Department of Epidemiology and Health Monitoring, Robert Koch Institute, 13302, Berlin, Germany. 5. University Hospital for Children and Adolescents, University of Leipzig, 04103, Leipzig, Germany. 6. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig, Germany.
Abstract
PURPOSE: Iodine deficiency in childhood and adolescence may lead to later thyroid dysfunction, stunted growth and cognitive impairment. The World Health Organization (WHO) has issued recommended age-dependent urine iodine concentration targets, but a critical threshold beyond which clinical sequelae are to be expected remains undefined. Our study aimed to investigate spot urine iodine concentration in a typical Central European cohort of children and adolescents, and consider the implications of these values in regard to laboratory parameters for evaluating thyroid function. METHODS: Using the Sandell-Kolthoff method, spot urine iodine concentration was measured cross-sectionally from 1802 healthy children and adolescent in the age range of 0.25-18 years within the LIFE-Child epidemiological study based in and around the city of Leipzig (Germany). Additionally, serum thyroid biomarkers of these subjects were measured and correlated to urine iodine levels. RESULTS: In our cohort, 61.39% of boys and 65.91% of girls had an iodine level of < 100 µg/L (57%, 67%, 65% of the age groups 0-5, 6-12 and 13-18 years), the median iodine excretion was 86 µg/L in boys and 80 µg/L in girls. The iodine levels revealed no significant correlation with the thyroid biomarkers TSH, FT4 and FT3. Moreover, iodine values revealed no correlation with levels of antibodies against thyroid peroxidase or thyroglobulin. CONCLUSION: In our cohort of children and adolescents, the relatively high number of iodine levels below the WHO recommendation appears not to be related to clinical or subclinical thyroid diseases in the respective participants.
PURPOSE:Iodine deficiency in childhood and adolescence may lead to later thyroid dysfunction, stunted growth and cognitive impairment. The World Health Organization (WHO) has issued recommended age-dependent urine iodine concentration targets, but a critical threshold beyond which clinical sequelae are to be expected remains undefined. Our study aimed to investigate spot urine iodine concentration in a typical Central European cohort of children and adolescents, and consider the implications of these values in regard to laboratory parameters for evaluating thyroid function. METHODS: Using the Sandell-Kolthoff method, spot urine iodine concentration was measured cross-sectionally from 1802 healthy children and adolescent in the age range of 0.25-18 years within the LIFE-Child epidemiological study based in and around the city of Leipzig (Germany). Additionally, serum thyroid biomarkers of these subjects were measured and correlated to urine iodine levels. RESULTS: In our cohort, 61.39% of boys and 65.91% of girls had an iodine level of < 100 µg/L (57%, 67%, 65% of the age groups 0-5, 6-12 and 13-18 years), the median iodine excretion was 86 µg/L in boys and 80 µg/L in girls. The iodine levels revealed no significant correlation with the thyroid biomarkers TSH, FT4 and FT3. Moreover, iodine values revealed no correlation with levels of antibodies against thyroid peroxidase or thyroglobulin. CONCLUSION: In our cohort of children and adolescents, the relatively high number of iodine levels below the WHO recommendation appears not to be related to clinical or subclinical thyroid diseases in the respective participants.
Authors: Daniela M C Miranda; Juliana N Massom; Regina M Catarino; Raimunda T M Santos; Sônia S Toyoda; Marília M S Marone; Eduardo K Tomimori; Osmar Monte Journal: Thyroid Date: 2015-01 Impact factor: 6.568
Authors: Till Ittermann; Simone Johner; Harald Below; Matthias Leiterer; Michael Thamm; Thomas Remer; Henry Völzke Journal: Clin Chem Lab Med Date: 2018-02-23 Impact factor: 3.694
Authors: Simone A Johner; Michael Thamm; Peter Stehle; Ute Nöthlings; Eugen Kriener; Henry Völzke; Roland Gärtner; Thomas Remer Journal: Thyroid Date: 2014-06-05 Impact factor: 6.568
Authors: Henry Völzke; Iris Erlund; Alicja Hubalewska-Dydejczyk; Till Ittermann; Robin P Peeters; Margaret Rayman; Monika Buchberger; Uwe Siebert; Betina H Thuesen; Michael B Zimmermann; Stefan Grünert; John H Lazarus Journal: Eur Thyroid J Date: 2018-07-31