| Literature DB >> 32390019 |
Pablo Valverde1, Jean-Baptiste Vendeville2, Kristian Hollingsworth3, Ashley P Mattey4, Tessa Keenan5, Harriet Chidwick5, Helene Ledru6, Kler Huonnic2, Kun Huang4, Mark E Light2, Nicholas Turner4, Jesús Jiménez-Barbero7, M Carmen Galan6, Martin A Fascione5, Sabine Flitsch4, W Bruce Turnbull3, Bruno Linclau2.
Abstract
The first synthesis of 3-deoxy-3-fluoro-l-fucose is presented, which employs a d- to l-sugar translation strategy, and involves an enzymatic oxidation of 3-deoxy-3-fluoro-l-fucitol. Enzymatic activation (FKP) and glycosylation using an α-1,2 and an α-1,3 fucosyltransferase to obtain two fluorinated trisaccharides demonstrates its potential as a novel versatile chemical probe in glycobiology.Entities:
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Year: 2020 PMID： 32390019 DOI： 10.1039/d0cc02209h
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222