Literature DB >> 32390012

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds.

Hualong Song1, Nicola J Rogers1, Viktor Brabec2, Guy J Clarkson1, James P C Coverdale1, Hana Kostrhunova2, Roger M Phillips3, Miles Postings1, Samantha L Shepherd3, Peter Scott1.   

Abstract

Functionalised triazole aldehydes are used in the highly selective self-assembly of water-compatible, optically pure, low symmetry Fe(ii)- and Zn(ii)-based metallohelices. Sub-micromolar antiproliferative activity is observed against various cancerous cell lines, accompanied by excellent selectivity versus non-cancerous cells and potential for synergistic combinatorial therapy with cisplatin.

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Year:  2020        PMID： 32390012     DOI： 10.1039/d0cc02429e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Solvent-Dependent Reactivity and Photochemistry of Dinuclear and Mononuclear Platinum(IV) Azido Triazaolato Complexes.

Authors:  Kezi Yao; Arnau Bertran; Jacques Morgan; Charlotte Greenhalgh; Katharina Edkins; Alice M Bowen; Nicola J Farrer
Journal:  Eur J Inorg Chem       Date:  2021-03-16       Impact factor: 2.524

2.  Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells.

Authors:  Liang Yan; Yi Liu; Xue-Feng Ma; Dan Hou; Yu-Hui Zhang; Yong Sun; Shan-Shan Shi; Tim Forouzanfar; Hai-Yan Lin; Jun Fan; Gang Wu
Journal:  Front Pharmacol       Date:  2021-07-08       Impact factor: 5.810

3.  Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles.

Authors:  Jaroslav Malina; Hana Kostrhunova; Vojtech Novohradsky; Peter Scott; Viktor Brabec
Journal:  Nucleic Acids Res       Date:  2022-01-25       Impact factor: 16.971

4.  Cavity-Containing [Fe2L3]4+ Helicates: An Examination of Host-Guest Chemistry and Cytotoxicity.

Authors:  Lynn S Lisboa; Mie Riisom; Roan A S Vasdev; Stephen M F Jamieson; L James Wright; Christian G Hartinger; James D Crowley
Journal:  Front Chem       Date:  2021-07-07       Impact factor: 5.221

5.  Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo.

Authors:  Hualong Song; Simon J Allison; Viktor Brabec; Hannah E Bridgewater; Jana Kasparkova; Hana Kostrhunova; Vojtech Novohradsky; Roger M Phillips; Jitka Pracharova; Nicola J Rogers; Samantha L Shepherd; Peter Scott
Journal:  Angew Chem Int Ed Engl       Date:  2020-07-07       Impact factor: 15.336
  5 in total

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