Pauline E van Beek1, Nathalie H P Claessens2, Antonios Makropoulos3, Floris Groenendaal2, Linda S de Vries2, Serena J Counsell4, Manon J N L Benders2. 1. Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: pauline.van.beek@mmc.nl. 2. Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands; Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands. 3. Department of Computing, Imperial College London, London, United Kingdom. 4. Centre for the Developing Brain, Division of Imaging Science & Biomedical Engineering, King's College London, London, United Kingdom.
Abstract
OBJECTIVE: To assess the effect of early life nutrition on structural brain development in two cohorts of extremely preterm infants, before and after implementation of a nutrition regimen containing more protein and lipid. STUDY DESIGN: 178 infants were retrospectively included (median gestational age 26.6 wks, IQR 25.9 - 27.3), of whom 99 received the old nutrition regimen (cohort A, 2011-2013) and 79 the new nutrition regimen (cohort B, 2013-2015). Intake of protein, lipids and calories was calculated for the first 28 postnatal days. Brain MRI was performed at 30 weeks post-menstrual age (PMA) (IQR 30.3-31.4) and term-equivalent age (TEA) (IQR 40.9-41.4). Volumes of 42 (left + right) brain structures were calculated. RESULTS: Mean protein and caloric intake in cohort B (3.4 g/kg/day; p<0.001 and 109 kCal/kg/day; P = .038) were higher than in cohort A (2.7 g/kg/day; 104 kCal/kg/day). At 30 weeks, 22 regions were significantly larger in cohort B compared with cohort A, whereas at TEA, only the caudate nucleus was significantly larger in cohort B compared with cohort A. CONCLUSIONS: An optimized nutrition protocol in the first 28 days of life is associated with temporarily improved early life brain volumes.
OBJECTIVE: To assess the effect of early life nutrition on structural brain development in two cohorts of extremely preterm infants, before and after implementation of a nutrition regimen containing more protein and lipid. STUDY DESIGN: 178 infants were retrospectively included (median gestational age 26.6 wks, IQR 25.9 - 27.3), of whom 99 received the old nutrition regimen (cohort A, 2011-2013) and 79 the new nutrition regimen (cohort B, 2013-2015). Intake of protein, lipids and calories was calculated for the first 28 postnatal days. Brain MRI was performed at 30 weeks post-menstrual age (PMA) (IQR 30.3-31.4) and term-equivalent age (TEA) (IQR 40.9-41.4). Volumes of 42 (left + right) brain structures were calculated. RESULTS: Mean protein and caloric intake in cohort B (3.4 g/kg/day; p<0.001 and 109 kCal/kg/day; P = .038) were higher than in cohort A (2.7 g/kg/day; 104 kCal/kg/day). At 30 weeks, 22 regions were significantly larger in cohort B compared with cohort A, whereas at TEA, only the caudate nucleus was significantly larger in cohort B compared with cohort A. CONCLUSIONS: An optimized nutrition protocol in the first 28 days of life is associated with temporarily improved early life brain volumes.
Authors: Sarah U Morton; Brian J Leyshon; Eleonora Tamilia; Rutvi Vyas; Michaela Sisitsky; Imran Ladha; John B Lasekan; Matthew J Kuchan; P Ellen Grant; Yangming Ou Journal: Front Psychiatry Date: 2022-06-23 Impact factor: 5.435
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