Yan Paccaud1,2, Magali Rios-Leyvraz3, Arnaud Chiolero4,5,6, Paloma Parvex7, Murielle Bochud3, René Tabin8,7, Bernard Genin8,7, Michel Russo8, Michel F Rossier7,9, Pascal Bovet3. 1. Hospital Center of Valais Romand, Hospital of Valais, Avenue Grand-Champsec 80, 0041276034147, 1950, Sion, Switzerland. yan.paccaud@hopitalvs.ch. 2. Faculty of Medicine, University of Geneva, Geneva, Switzerland. yan.paccaud@hopitalvs.ch. 3. Department of Epidemiology and Health Systems, Center for Primary Care and Public Health (Unisanté), Lausanne, Switzerland. 4. Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland. 5. Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland. 6. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada. 7. Faculty of Medicine, University of Geneva, Geneva, Switzerland. 8. Hospital Center of Valais Romand, Hospital of Valais, Avenue Grand-Champsec 80, 0041276034147, 1950, Sion, Switzerland. 9. Central Institute of Hospitals, Hospital of Valais, Sion, Switzerland.
Abstract
Urinary calcium/creatinine ratio (UCa/Cr) on a single spot urine sample is frequently used in children to evaluate calciuria, but its accuracy to estimate 24-h urinary calcium excretion (24hUCa) has not been properly assessed. We analyzed the correlation between UCa/Cr in various spot samples and 24hUCa among healthy children. A 24-h urine specimen and three spot urine samples (evening, first, and second morning) were collected in a convenience sample of children aged 6 to 16 years (n = 101). Measured 24hUCa was compared with UCa/Cr in each of the three spot samples. The ability of UCa/Cr to discriminate between children with and without hypercalciuria (calciuria > 4 mg/kg/24 h, 1 mmol/kg/24 h) and optimal timing of the spot sample were determined. Eighty-five children completed an adequate 24-h urine collection. Pearson correlation coefficients between the UCa/Cr on the spot sample and 24hUCa were 0.64, 0.71, and 0.52 for the evening, first, and second morning spot samples, respectively. Areas under the ROC curve were 0.90, 0.82, and 0.75, respectively, for the corresponding spot samples. Conclusion: The relatively strong correlation between 24hUCa and UCa/Cr in evening and first morning spot urine samples suggests that these spots could be preferred in clinical practice.Trial registration: ClinicalTrials.gov , NCT02900261, date of trial registration 14 September 2016. What is Known: •Urinary calcium/creatinine ratio on a single spot urine sample is frequently used as a proxy for 24-h urinary calcium excretion. •Correlation of these indicators, including the best timing for spot urine sampling, has not been properly assessed. What is New: •Relatively strong correlations were found between the calcium/creatinine ratio on a single spot urine sample and 24-h urinary calcium excretion in healthy children. •Evening and first morning spot samples had the highest correlation.
Urinary calcium/creatinine ratio (UCa/Cr) on a single spot urine sample is frequently used in children to evaluate calciuria, but its accuracy to estimate 24-h urinary calcium excretion (24hUCa) has not been properly assessed. We analyzed the correlation between UCa/Cr in various spot samples and 24hUCa among healthy children. A 24-h urine specimen and three spot urine samples (evening, first, and second morning) were collected in a convenience sample of children aged 6 to 16 years (n = 101). Measured 24hUCa was compared with UCa/Cr in each of the three spot samples. The ability of UCa/Cr to discriminate between children with and without hypercalciuria (calciuria > 4 mg/kg/24 h, 1 mmol/kg/24 h) and optimal timing of the spot sample were determined. Eighty-five children completed an adequate 24-h urine collection. Pearson correlation coefficients between the UCa/Cr on the spot sample and 24hUCa were 0.64, 0.71, and 0.52 for the evening, first, and second morning spot samples, respectively. Areas under the ROC curve were 0.90, 0.82, and 0.75, respectively, for the corresponding spot samples. Conclusion: The relatively strong correlation between 24hUCa and UCa/Cr in evening and first morning spot urine samples suggests that these spots could be preferred in clinical practice.Trial registration: ClinicalTrials.gov , NCT02900261, date of trial registration 14 September 2016. What is Known: •Urinary calcium/creatinine ratio on a single spot urine sample is frequently used as a proxy for 24-h urinary calcium excretion. •Correlation of these indicators, including the best timing for spot urine sampling, has not been properly assessed. What is New: •Relatively strong correlations were found between the calcium/creatinine ratio on a single spot urine sample and 24-h urinary calcium excretion in healthy children. •Evening and first morning spot samples had the highest correlation.
Authors: Moira E Dwyer; Amy E Krambeck; Eric J Bergstralh; Dawn S Milliner; John C Lieske; Andrew D Rule Journal: J Urol Date: 2012-05-15 Impact factor: 7.450
Authors: R J M Coward; C J Peters; P G Duffy; D Corry; M J Kellett; S Choong; W G van't Hoff Journal: Arch Dis Child Date: 2003-11 Impact factor: 3.791
Authors: In Su Choi; Eui Seok Jung; Young Earl Choi; Young Kuk Cho; Eun Mi Yang; Chan Jong Kim Journal: Ann Lab Med Date: 2013-10-17 Impact factor: 3.464