Camille P Vaughan1, Alayne D Markland2, Alison J Huang3, Vin Tangpricha4, Francine Grodstein5. 1. Birmingham/Atlanta Geriatric Research, Education, and Clinical Center (GRECC), Department of Veterans Affairs, Birmingham, AL and Atlanta, GA; Emory University, Department of Medicine, Atlanta, GA; Atlanta VA Medical Center, Decatur, GA. Electronic address: camille.vaughan@emory.edu. 2. Birmingham/Atlanta Geriatric Research, Education, and Clinical Center (GRECC), Department of Veterans Affairs, Birmingham, AL and Atlanta, GA; University of Alabama at Birmingham, Department of Medicine, Birmingham, AL. 3. University of California, San Francisco, Department of Medicine, San Francisco, CA. 4. Emory University, Department of Medicine, Atlanta, GA; Atlanta VA Medical Center, Decatur, GA. 5. Channing Division of Network Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Abstract
OBJECTIVE: To determine if vitamin D intake is associated with reduced progression of urgency urinary incontinence (UI) in women. METHODS: We used the Nurses' Health Study (NHS) I and NHSII cohorts to evaluate the association of vitamin D intake with progression of urgency UI and mixed UI, from mild-moderate to severe symptoms, from 2004 to 2012 (NHS) and 2005-2013 (NHSII). Intake of vitamin D at study baseline was categorized and updated at the start of each 2-4 year follow-up period. Multivariable-adjusted relative risks (RRs) and 95% confidence intervals (95% CI) of progression to severe UI were estimated using Cox proportional hazard models. RESULTS: At baseline, of the 20,560 older women (age range 58-73 years) in NHS I with mild/moderate urgency or mixed UI, 21% reported oral vitamin D intake of at least 800 IU per day. Among 12,573 middle-aged women (age range 42-59) in NHS II with mild/moderate urgency or mixed UI, 17% reported oral vitamin D intake of at least 800 IU daily. From 2004 to 2012, 4853 incident cases of urgency/mixed UI progression were identified among older women. From 2005 to 2013, 1378 incident cases of urgency/mixed UI progression were identified among middle-aged women. After multivariable adjustment, no significant associations between vitamin D intake and incidence of urgency/mixed UI progression were observed in either cohort (RR = 1.10, 95% CI 0.99-1.23 in older women, RR = 0.88, 95% CI 0.71, 1.10 in middle-aged women). CONCLUSION: Despite interest in vitamin D as a low-cost strategy to prevent or reduce UI, our findings indicate oral vitamin D may not reduce urgency/mixed UI progression. Published by Elsevier Inc.
OBJECTIVE: To determine if vitamin D intake is associated with reduced progression of urgency urinary incontinence (UI) in women. METHODS: We used the Nurses' Health Study (NHS) I and NHSII cohorts to evaluate the association of vitamin D intake with progression of urgency UI and mixed UI, from mild-moderate to severe symptoms, from 2004 to 2012 (NHS) and 2005-2013 (NHSII). Intake of vitamin D at study baseline was categorized and updated at the start of each 2-4 year follow-up period. Multivariable-adjusted relative risks (RRs) and 95% confidence intervals (95% CI) of progression to severe UI were estimated using Cox proportional hazard models. RESULTS: At baseline, of the 20,560 older women (age range 58-73 years) in NHS I with mild/moderate urgency or mixed UI, 21% reported oral vitamin D intake of at least 800 IU per day. Among 12,573 middle-aged women (age range 42-59) in NHS II with mild/moderate urgency or mixed UI, 17% reported oral vitamin D intake of at least 800 IU daily. From 2004 to 2012, 4853 incident cases of urgency/mixed UI progression were identified among older women. From 2005 to 2013, 1378 incident cases of urgency/mixed UI progression were identified among middle-aged women. After multivariable adjustment, no significant associations between vitamin D intake and incidence of urgency/mixed UI progression were observed in either cohort (RR = 1.10, 95% CI 0.99-1.23 in older women, RR = 0.88, 95% CI 0.71, 1.10 in middle-aged women). CONCLUSION: Despite interest in vitamin D as a low-cost strategy to prevent or reduce UI, our findings indicate oral vitamin D may not reduce urgency/mixed UI progression. Published by Elsevier Inc.
Authors: Candace Y Parker-Autry; Alayne D Markland; Alicia C Ballard; Deidra Downs-Gunn; Holly E Richter Journal: Int Urogynecol J Date: 2012-03-08 Impact factor: 2.894
Authors: Alayne D Markland; Vin Tangpricha; T Mark Beasley; Camille P Vaughan; Holly E Richter; Kathryn L Burgio; Patricia S Goode Journal: J Am Geriatr Soc Date: 2018-12-21 Impact factor: 5.562
Authors: Vatche A Minassian; Kaitlin A Hagan; Elisabeth Erekson; Andrea M Austin; Donald Carmichael; Julie P W Bynum; Francine Grodstein Journal: Am J Obstet Gynecol Date: 2019-08-23 Impact factor: 8.661
Authors: Yong Zhang; Donald Y M Leung; Brittany N Richers; Yusen Liu; Linda K Remigio; David W Riches; Elena Goleva Journal: J Immunol Date: 2012-02-01 Impact factor: 5.422
Authors: C P Vaughan; Vin Tangpricha; N Motahar-Ford; P S Goode; K L Burgio; R M Allman; S G Daigle; D T Redden; A D Markland Journal: Eur J Clin Nutr Date: 2016-03-16 Impact factor: 4.016