Research progress in relation of Helicobacter pylori infection with pregnancy-related diseases and adverse pregnancy outcomes.

Helicobacter pylori (Hp) is a Gram-negative microaerobic bacterium, which is parasitic on gastric mucosa and is associated with the pathogenesis of chronic gastritis, gastric ulcer, gastric cancer and other gastric diseases. Meanwhile, the Hp infection is related with pregnancy-related diseases, pregnancy outcomes, and the health status of offspring, such as infertility, premature delivery, abortion, Hp infection of newborn and neural tube defects. Hp infection is also related to hyperemesis of pregnancy, preeclampsia, gestational diabetes mellitus, iron deficiency anemia, idiopathic thrombocytopenic purpura. It has been suggested that early diagnosis and eradication of Hp and standardized the anti-Hp treatment will benefit pregnant women and their offspring.