Horng-Jinh Chang1, Kuan-Reng Lin2, Meng-Te Lin3, Junn-Liang Chang4,5. 1. Department of Management Sciences, Tamkang University, No.151, Yingzhuan Rd., Tamsui Dist, New Taipei City, 25137, Taiwan, Republic of China. 2. Department of Management Sciences, Tamkang University, No.151, Yingzhuan Rd., Tamsui Dist, New Taipei City, 25137, Taiwan, Republic of China. kittylintku@gms.tku.edu.tw. 3. Department of Pathology & Laboratory Medicine, Taoyuan Armed Forces General Hospital, No.168, Chung-Shing Rd., Long-Tang District, Taoyuan City, 325, Taiwan, Republic of China. 4. Department of Pathology & Laboratory Medicine, Taoyuan Armed Forces General Hospital, No.168, Chung-Shing Rd., Long-Tang District, Taoyuan City, 325, Taiwan, Republic of China. junn9liang@yahoo.com.tw. 5. Biomedical Engineering Department, Ming Chuan University, Taoyuan City, 333, Taiwan. junn9liang@yahoo.com.tw.
Abstract
BACKGROUND: Impaired kidney function is the hallmark of chronic kidney disease (CKD), and is associated with increased risk of all-cause mortality in the elderly. In the present cross-sectional population-based study, we aimed to evaluate the associations between lifestyle factors (exercise habit, alcohol consumption, smoking history, and betel nut chewing) and decreased kidney function. METHODS: The data from the Taipei City Elderly Health Examination Database (2006 to 2012) were extracted. Associations between risk factors and reduced estimated Glomerular filtration rate (eGFR) were evaluated by regression and stratification analyses. RESULTS: A total of 297,603 participants were included in the final analysis, and 29.7% of them had reduced eGFR. Smoking was significantly associated with an elevated risk of reduced eGFR. While, physical exercise conferred to a significantly decreased adjusted odds ratio (aOR) in reduced eGFR (regular exercise, aOR = 0.79; occasional exercise, aOR = 0.87). Furthermore, the protective effect of exercise habit against reduced eGFR was not affected by comorbid conditions, such as hypertension, diabetes, obesity, and cardiovascular disease. CONCLUSIONS: Engaging in physical exercise was beneficially associated with reduced eGFR in older individuals. Longitudinal or prospective studies are warranted for confirmation and extrapolation of the current findings.
BACKGROUND:Impaired kidney function is the hallmark of chronic kidney disease (CKD), and is associated with increased risk of all-cause mortality in the elderly. In the present cross-sectional population-based study, we aimed to evaluate the associations between lifestyle factors (exercise habit, alcohol consumption, smoking history, and betel nut chewing) and decreased kidney function. METHODS: The data from the Taipei City Elderly Health Examination Database (2006 to 2012) were extracted. Associations between risk factors and reduced estimated Glomerular filtration rate (eGFR) were evaluated by regression and stratification analyses. RESULTS: A total of 297,603 participants were included in the final analysis, and 29.7% of them had reduced eGFR. Smoking was significantly associated with an elevated risk of reduced eGFR. While, physical exercise conferred to a significantly decreased adjusted odds ratio (aOR) in reduced eGFR (regular exercise, aOR = 0.79; occasional exercise, aOR = 0.87). Furthermore, the protective effect of exercise habit against reduced eGFR was not affected by comorbid conditions, such as hypertension, diabetes, obesity, and cardiovascular disease. CONCLUSIONS: Engaging in physical exercise was beneficially associated with reduced eGFR in older individuals. Longitudinal or prospective studies are warranted for confirmation and extrapolation of the current findings.