Isabelle Rouch1,2, Catherine Padovan3,4, Nawèle Boublay2, Elodie Pongan1,2, Bernard Laurent1,5, Béatrice Trombert-Paviot6, Pierre Krolak-Salmon2,7, Jean-Michel Dorey3,7. 1. Memory Clinical and Research Center of Saint-Etienne (CMRR), Neurology Unit, University Hospital of Saint-Etienne, Saint-Etienne, France. 2. Memory Clinical and Research Center of Lyon (CMRR), Aging Institute I-Vie, University Hospital of Lyon, Villeurbanne, France. 3. Aging Psychiatry Unit, University Hospital Le Vinatier, Bron, France. 4. DIPHE Laboratory, Lyon 2 University, Lyon, France. 5. Neuropain Team, Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France. 6. Public Health and Medical Information Unit, University Hospital of Saint-Etienne, Saint-Etienne, France. 7. Brain Dynamics and Cognition, Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR 5292, Lyon, France.
Abstract
OBJECTIVE: This study was aimed at evaluating the association between cognitive functioning and the occurrence of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD). METHODS/ DESIGN: The population is derived from the PACO cohort, including 237 patients with prodromal or mild AD. A neuropsychological tests battery exploring verbal and visual memory, language, attention, and executive functions was performed at baseline. BPSD were assessed at 6-, 12-, and 18-month follow-up with neuropsychiatric inventory (NPI). RESULTS: Lower baseline performance on Stroop test interference score was associated with higher subsequent overall NPI scores (P = .006), subscores of anxiety/depression (P = .03), and apathy inventory (P = .01). Conversely, other executive functions, verbal or visual memory, and language performances were not associated with a higher risk of BPSD. CONCLUSION: Our results suggest that poorer inhibition performance would be associated with a higher risk of 18-month BPSD occurrence, including anxiety, depression, and apathy. A better knowledge of the predictive factors of the BPSDs would make it possible to better identify the patients at risk, to propose preventive strategies and an earlier adapted care. J Am Geriatr Soc 68:-, 2020.
OBJECTIVE: This study was aimed at evaluating the association between cognitive functioning and the occurrence of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD). METHODS/ DESIGN: The population is derived from the PACO cohort, including 237 patients with prodromal or mild AD. A neuropsychological tests battery exploring verbal and visual memory, language, attention, and executive functions was performed at baseline. BPSD were assessed at 6-, 12-, and 18-month follow-up with neuropsychiatric inventory (NPI). RESULTS: Lower baseline performance on Stroop test interference score was associated with higher subsequent overall NPI scores (P = .006), subscores of anxiety/depression (P = .03), and apathy inventory (P = .01). Conversely, other executive functions, verbal or visual memory, and language performances were not associated with a higher risk of BPSD. CONCLUSION: Our results suggest that poorer inhibition performance would be associated with a higher risk of 18-month BPSD occurrence, including anxiety, depression, and apathy. A better knowledge of the predictive factors of the BPSDs would make it possible to better identify the patients at risk, to propose preventive strategies and an earlier adapted care. J Am Geriatr Soc 68:-, 2020.
Authors: Juan Luis Sánchez-Rodríguez; Raúl Juárez-Vela; Iván Santolalla-Arnedo; Regina Ruiz de Viñaspre-Hernandez; Juan Luis Sánchez-González Journal: J Pers Med Date: 2022-03-29
Authors: Willem S Eikelboom; Esther van den Berg; Ellen H Singleton; Sara J Baart; Michiel Coesmans; Annebet E Leeuwis; Charlotte E Teunissen; Bart N M van Berckel; Yolande A L Pijnenburg; Philip Scheltens; Wiesje M van der Flier; Rik Ossenkoppele; Janne M Papma Journal: Neurology Date: 2021-08-19 Impact factor: 9.910