Mònica Girona-Alarcón1,2, Elena Fresán1,2, Ana Garcia-Garcia3, Sara Bobillo-Perez1,2, Monica Balaguer1,2, Aida Felipe1,2, Maria Esther Esteban4, Iolanda Jordan1,2,5. 1. Paediatric Intensive Care Unit, Institut de Recerca Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain. 2. Immunological and Respiratory Disorders in the Paediatric Critical Patient Research Group, Institut de Recerca Hospital Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain. 3. Immunology Department, Hospital Sant Joan de Déu-Clínic, University of Barcelona, Barcelona, Spain. 4. Zoology and Anthropology Section, Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, GREAB- Biological Anthropology Research Group, Institut de Recerca de la Biodiversitat (IRBio), University of Barcelona, Barcelona, Spain. 5. Paediatric Intensive Care Unit, CIBERESP, Hospital Sant Joan de Déu-Clínic, University of Barcelona, Barcelona, Spain.
Abstract
AIM: Multidrug-resistant bacterial infections are a public health problem worldwide. However, most of the information available refers to adults. The main objectives were to determine the incidence, risk factors, and outcomes for device-associated infections, especially those involving multidrug-resistant bacteria. METHODS: This is a prospective, observational study. Children aged ≥1 month and <18 years admitted to the paediatric intensive care unit from 2008 to 2017, with a device-associated infection microbiologically confirmed were included. Patients infected with resistant bacteria were compared with those who had a drug-susceptible infection. RESULTS: The study included 213 patients. Out of all the device-associated infections, 22% (48 patients) were caused by multidrug-resistant bacteria. The most frequent were extended-spectrum beta-lactamase (ESBL)-producing enterobacteria. Cardiovascular diseases, age under 1year, comorbidity, prolonged use of invasive device, and length of stay until infection were risk factors for resistant bacteria, but not specifically for ESBL-producing bacteria. Length of stay and mortality was increased in patients with multidrug-resistant bacteria. CONCLUSION: Being under 1-year-old and having a cardiovascular disease were the two major risk factors for resistant bacterial infection. ESBL-producing bacteria were the most frequent multidrug-resistant agents. However, patients with ESBL-producing bacteria did not have any additional risk factors, so they may have been colonised in the community.
AIM: Multidrug-resistant bacterial infections are a public health problem worldwide. However, most of the information available refers to adults. The main objectives were to determine the incidence, risk factors, and outcomes for device-associated infections, especially those involving multidrug-resistant bacteria. METHODS: This is a prospective, observational study. Children aged ≥1 month and <18 years admitted to the paediatric intensive care unit from 2008 to 2017, with a device-associated infection microbiologically confirmed were included. Patientsinfected with resistant bacteria were compared with those who had a drug-susceptible infection. RESULTS: The study included 213 patients. Out of all the device-associated infections, 22% (48 patients) were caused by multidrug-resistant bacteria. The most frequent were extended-spectrum beta-lactamase (ESBL)-producing enterobacteria. Cardiovascular diseases, age under 1year, comorbidity, prolonged use of invasive device, and length of stay until infection were risk factors for resistant bacteria, but not specifically for ESBL-producing bacteria. Length of stay and mortality was increased in patients with multidrug-resistant bacteria. CONCLUSION: Being under 1-year-old and having a cardiovascular disease were the two major risk factors for resistant bacterial infection. ESBL-producing bacteria were the most frequent multidrug-resistant agents. However, patients with ESBL-producing bacteria did not have any additional risk factors, so they may have been colonised in the community.
Authors: Maria Hernandez-Garcia; Monica Girona-Alarcon; Sara Bobillo-Perez; Mireia Urrea-Ayala; Anna Sole-Ribalta; Mònica Balaguer; Francisco-José Cambra; Iolanda Jordan Journal: PLoS One Date: 2022-07-14 Impact factor: 3.752
Authors: Barbara Barduchi Oliveira da Silva; Moacyr Silva Júnior; Fernando Gatti de Menezes; Eduardo Juan Troster Journal: Einstein (Sao Paulo) Date: 2022-04-22