| Literature DB >> 32383070 |
Yan Zheng1,2, Tao Huang3, Tiange Wang4,5, Zhendong Mei6, Zhonghan Sun6, Tao Zhang3,7, Christina Ellervik8,9,10,11, Jin-Fang Chai12, Xueling Sim12, Rob M van Dam12, E-Shyong Tai12,13, Woon-Puay Koh12,14, Rajkumar Dorajoo15, Seang-Mei Saw12,16,17, Charumathi Sabanayagam16,17, Tien Yin Wong16,17, Preeti Gupta17, Peter Rossing8, Tarunveer S Ahluwalia18,19, Rebecca K Vinding19, Hans Bisgaard19, Klaus Bønnelykke19, Yujie Wang20, Mariaelisa Graff20, Trudy Voortman21, Frank J A van Rooij21, Albert Hofman21,22, Diana van Heemst23, Raymond Noordam23, Angela C Estampador24, Tibor V Varga24, Cornelia Enzenbach25,26, Markus Scholz25,26,27, Joachim Thiery26,27, Ralph Burkhardt26,27,28, Marju Orho-Melander29, Christina-Alexandra Schulz29, Ulrika Ericson29, Emily Sonestedt29, Michiaki Kubo30, Masato Akiyama30, Ang Zhou31,32, Tuomas O Kilpeläinen33, Torben Hansen33, Marcus E Kleber34,35,36, Graciela Delgado34, Mark McCarthy37, Rozenn N Lemaitre38, Janine F Felix39,40,41, Vincent W V Jaddoe39,40,41, Ying Wu42, Karen L Mohlke42, Terho Lehtimäki43,44, Carol A Wang45, Craig E Pennell45, Heribert Schunkert46, Thorsten Kessler46, Lingyao Zeng46, Christina Willenborg44, Annette Peters47, Wolfgang Lieb47, Veit Grote48, Peter Rzehak48, Berthold Koletzko48, Jeanette Erdmann49, Matthias Munz49,50, Tangchun Wu51, Meian He51, Caizheng Yu51, Cécile Lecoeur52,53, Philippe Froguel52,53, Dolores Corella54,55, Luis A Moreno55,56, Chao-Qiang Lai57, Niina Pitkänen58, Colin A Boreham59, Paul M Ridker60, Frits R Rosendaal61, Renée de Mutsert61, Chris Power62, Lavinia Paternoster63, Thorkild I A Sørensen34,63,64, Anne Tjønneland65, Kim Overvad66,67, Luc Djousse68, Fernando Rivadeneira39,40,69, Nanette R Lee70,71, Olli T Raitakari58,72,73, Mika Kähönen74,75, Jorma Viikari76,77, Jean-Paul Langhendries78, Joaquin Escribano79, Elvira Verduci80, George Dedoussis81, Inke König82, Beverley Balkau83,84,85, Oscar Coltell55,86, Jean Dallongeville87, Aline Meirhaeghe87, Philippe Amouyel87, Frédéric Gottrand88, Katja Pahkala58,73,89, Harri Niinikoski90,91, Elina Hyppönen62,31,32, Winfried März34,92,93, David A Mackey94, Dariusz Gruszfeld95, Katherine L Tucker96, Frédéric Fumeron97,98,99, Ramon Estruch55,100, Jose M Ordovas57,101, Donna K Arnett102, Dennis O Mook-Kanamori61,103, Dariush Mozaffarian104, Bruce M Psaty38,105,106,107, Kari E North20,108, Daniel I Chasman60,68, Lu Qi109.
Abstract
Epidemiology studies suggested that low birthweight was associated with a higher risk of hypertension in later life. However, little is known about the causality of such associations. In our study, we evaluated the causal association of low birthweight with adulthood hypertension following a standard analytic protocol using the study-level data of 183,433 participants from 60 studies (CHARGE-BIG consortium), as well as that with blood pressure using publicly available summary-level genome-wide association data from EGG consortium of 153,781 participants, ICBP consortium and UK Biobank cohort together of 757,601 participants. We used seven SNPs as the instrumental variable in the study-level analysis and 47 SNPs in the summary-level analysis. In the study-level analyses, decreased birthweight was associated with a higher risk of hypertension in adults (the odds ratio per 1 standard deviation (SD) lower birthweight, 1.22; 95% CI 1.16 to 1.28), while no association was found between genetically instrumented birthweight and hypertension risk (instrumental odds ratio for causal effect per 1 SD lower birthweight, 0.97; 95% CI 0.68 to 1.41). Such results were consistent with that from the summary-level analyses, where the genetically determined low birthweight was not associated with blood pressure measurements either. One SD lower genetically determined birthweight was not associated with systolic blood pressure (β = - 0.76, 95% CI - 2.45 to 1.08 mmHg), 0.06 mmHg lower diastolic blood pressure (β = - 0.06, 95% CI - 0.93 to 0.87 mmHg), or pulse pressure (β = - 0.65, 95% CI - 1.38 to 0.69 mmHg, all p > 0.05). Our findings suggest that the inverse association of birthweight with hypertension risk from observational studies was not supported by large Mendelian randomization analyses.Entities:
Keywords: Birthweight; Blood pressure; Causal association; Hypertension; Mendelian randomization
Mesh：
Year: 2020 PMID： 32383070 PMCID： PMC7867117 DOI： 10.1007/s10654-020-00638-z
Source DB: PubMed Journal: Eur J Epidemiol ISSN： 0393-2990 Impact factor: 8.082