Literature DB >> 3238053

Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea.

L Grundemar1, E Widmark, B Waldeck, R Håkanson.   

Abstract

The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

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Year:  1988        PMID: 3238053     DOI: 10.1016/0167-0115(88)90231-5

Source DB:  PubMed          Journal:  Regul Pept        ISSN: 0167-0115


  4 in total

1.  Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

Authors:  S A Thayer; R J Miller
Journal:  J Physiol       Date:  1990-06       Impact factor: 5.182

2.  Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways.

Authors:  L Grundemar; N Grundström; I G Johansson; R G Andersson; R Håkanson
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

3.  Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat.

Authors:  D Bleakman; N L Harrison; W F Colmers; R J Miller
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

4.  Presynaptic inhibitory effects of the peptides NPY, PYY and PP on nicotinic EPSPs in guinea-pig gastric myenteric neurones.

Authors:  M Schemann; K Tamura
Journal:  J Physiol       Date:  1992       Impact factor: 5.182

  4 in total

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