Tjardo S Postma1,2,3, Claire Cury4,5,6, Sallie Baxendale1, Pamela J Thompson1, Irene Cano-López1,7, Jane de Tisi1, Jane L Burdett2, Meneka K Sidhu1,2, Lorenzo Caciagli1,2, Gavin P Winston1,2,8, Sjoerd B Vos1,2,8, Maria Thom1, John S Duncan1,2, Matthias J Koepp1,2, Marian Galovic1,2,9. 1. Department of Clinical and Experimental Epilepsy, University College London Queen Square Institute of Neurology, London, United Kingdom. 2. MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom. 3. GGZ inGeest Specialized Mental Health Care, Amsterdam, the Netherlands. 4. Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom. 5. University of Rennes, Inria, Inserm, CNRS, IRISA UMR 6074, Empenn team ERL U 1228, F-35000, Rennes, France. 6. Centre for Medical Image Computing, University College London, London, United Kingdom. 7. Valencian International University, Valencia, Spain. 8. Department of Medicine, Division of Neurology, Queen's University, Kingston, Canada. 9. Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
Abstract
OBJECTIVE: Cognitive problems, especially disturbances in episodic memory, and hippocampal sclerosis are common in temporal lobe epilepsy (TLE), but little is known about the relationship of hippocampal morphology with memory. We aimed to relate hippocampal surface-shape patterns to verbal and visual learning. METHODS: We analyzed hippocampal surface shapes on high-resolution magnetic resonance images and the Adult Memory and Information Processing Battery in 145 unilateral refractory TLE patients undergoing epilepsy surgery, a validation set of 55 unilateral refractory TLE patients, and 39 age- and sex-matched healthy volunteers. RESULTS: Both left TLE (LTLE) and right TLE (RTLE) patients had lower verbal (LTLE 44 ± 11; RTLE 45 ± 10) and visual learning (LTLE 34 ± 8, RTLE 30 ± 8) scores than healthy controls (verbal 58 ± 8, visual 39 ± 6; p < 0.001). Verbal learning was more impaired the greater the atrophy of the left superolateral hippocampal head. In contrast, visual memory was worse with greater bilateral inferomedial hippocampal atrophy. Postsurgical verbal memory decline was more common in LTLE than in RTLE (reliable change index in LTLE 27% vs RTLE 7%, p = 0.006), whereas there were no differences in postsurgical visual memory decline between those groups. Preoperative atrophy of the left hippocampal tail predicted postsurgical verbal memory decline. INTERPRETATION: Memory deficits in TLE are associated with specific morphological alterations of the hippocampus, which could help stratify TLE patients into those at high versus low risk of presurgical or postsurgical memory deficits. This knowledge could improve planning and prognosis of selective epilepsy surgery and neuropsychological counseling in TLE. ANN NEUROL 2020.
OBJECTIVE: Cognitive problems, especially disturbances in episodic memory, and hippocampal sclerosis are common in temporal lobe epilepsy (TLE), but little is known about the relationship of hippocampal morphology with memory. We aimed to relate hippocampal surface-shape patterns to verbal and visual learning. METHODS: We analyzed hippocampal surface shapes on high-resolution magnetic resonance images and the Adult Memory and Information Processing Battery in 145 unilateral refractory TLEpatients undergoing epilepsy surgery, a validation set of 55 unilateral refractory TLEpatients, and 39 age- and sex-matched healthy volunteers. RESULTS: Both left TLE (LTLE) and right TLE (RTLE) patients had lower verbal (LTLE 44 ± 11; RTLE 45 ± 10) and visual learning (LTLE 34 ± 8, RTLE 30 ± 8) scores than healthy controls (verbal 58 ± 8, visual 39 ± 6; p < 0.001). Verbal learning was more impaired the greater the atrophy of the left superolateral hippocampal head. In contrast, visual memory was worse with greater bilateral inferomedial hippocampal atrophy. Postsurgical verbal memory decline was more common in LTLE than in RTLE (reliable change index in LTLE 27% vs RTLE 7%, p = 0.006), whereas there were no differences in postsurgical visual memory decline between those groups. Preoperative atrophy of the left hippocampal tail predicted postsurgical verbal memory decline. INTERPRETATION:Memory deficits in TLE are associated with specific morphological alterations of the hippocampus, which could help stratify TLEpatients into those at high versus low risk of presurgical or postsurgical memory deficits. This knowledge could improve planning and prognosis of selective epilepsy surgery and neuropsychological counseling in TLE. ANN NEUROL 2020.
Authors: E Conde-Blanco; J C Pariente; M Carreño; T Boget; S Pascual-Díaz; M Centeno; I Manzanares; A Donaire; L Pintor; J Rumià; P Roldán; X Setoain; N Bargalló Journal: AJNR Am J Neuroradiol Date: 2022-09-22 Impact factor: 4.966
Authors: Josephine Heine; Harald Prüß; Michael Scheel; Alexander U Brandt; Stefan M Gold; Thorsten Bartsch; Friedemann Paul; Carsten Finke Journal: Neuroimage Clin Date: 2020-11-27 Impact factor: 4.881
Authors: Daichi Sone; Maria Ahmad; Pamela J Thompson; Sallie Baxendale; Sjoerd B Vos; Fenglai Xiao; Jane de Tisi; Andrew W McEvoy; Anna Miserocchi; John S Duncan; Matthias J Koepp; Marian Galovic Journal: Ann Neurol Date: 2021-11-20 Impact factor: 11.274