Pan Xiong1, Li Niu2, Sam Talaei3, Hamed Kord-Varkaneh4, Cain C T Clark5, Mihnea-Alexandru Găman6, Jamal Rahmani4, Masoumeh Dorosti7, Seyed Mohammad Mousavi8, Meysam Zarezadeh9, Hossein Taghizade-Bilondi4, Jitao Zhang10. 1. Department of Cardiovasology, The Second People's Hospital of Liaocheng, Linqing, Shandong Province, 252600, China. 2. Department of Cadre Health Care, Qingdao Municipal Hospital, Qingdao, Shandong Province, 266011, China. 3. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Student Research Committee, Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Centre for Sport, Exercise, and Life Sciences, Coventry University, Coventry, CV15FB, UK. 6. Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474, Bucharest, Romania. 7. Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. 8. Department of Community Nutrition, Students' Scientific Research Center (SSRC), School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 9. Department of Clinical Nutrition, Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. 10. Department of Cardiology, Qingdao Hiser Medical Center, No.4, People's Road, Sifang District, Qingdao, Shandong Province, 266033, China. Electronic address: zhangjt2019@sina.com.
Abstract
BACKGROUND: and purpose: Clinical studies investigating the effects of berberine supplementation on anthropometric indices in humans have generated inconsistent results. Thus, the objective of this systematic review and meta-analysis was to clarify the effects of berberine supplementation on obesity indices in human subjects. METHODS: Several online medical databases were systematically searched up to February 2019. All clinical trials exploring the effects of berberine supplementation on indices of obesity were included. The combined weighted mean difference (WMD) of eligible studies was assessed using a random-effects model. We evaluated publication bias by using the Egger's test. RESULTS: Overall, 10 studies were included. The combined outcomes suggested a significant influence of berberine administration on body mass index (BMI) (WMD: -0.29 kg/m2, 95% CI: -0.51 to -0.08, p = 0.006) and waist circumference (WC) (WMD: -2.75 cm, 95% CI: -4.88 to -0.62, p = 0.01). However, berberine supplementation yielded no significant decline in body weight (BW) (WMD: -0.11 kg, 95% CI: -0.99 to 0.76, p = 0.79). Following the dose-response evaluation, berberine intake was found to significantly reduce BMI (r = -0.02) and WC (r = -0.72) based on treatment duration. CONCLUSION: The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
BACKGROUND: and purpose: Clinical studies investigating the effects of berberine supplementation on anthropometric indices in humans have generated inconsistent results. Thus, the objective of this systematic review and meta-analysis was to clarify the effects of berberine supplementation on obesity indices in human subjects. METHODS: Several online medical databases were systematically searched up to February 2019. All clinical trials exploring the effects of berberine supplementation on indices of obesity were included. The combined weighted mean difference (WMD) of eligible studies was assessed using a random-effects model. We evaluated publication bias by using the Egger's test. RESULTS: Overall, 10 studies were included. The combined outcomes suggested a significant influence of berberine administration on body mass index (BMI) (WMD: -0.29 kg/m2, 95% CI: -0.51 to -0.08, p = 0.006) and waist circumference (WC) (WMD: -2.75 cm, 95% CI: -4.88 to -0.62, p = 0.01). However, berberine supplementation yielded no significant decline in body weight (BW) (WMD: -0.11 kg, 95% CI: -0.99 to 0.76, p = 0.79). Following the dose-response evaluation, berberine intake was found to significantly reduce BMI (r = -0.02) and WC (r = -0.72) based on treatment duration. CONCLUSION: The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
Authors: Laine de Carvalho Guerra Pessoa Mamede; Rafaela Lira Formiga Cavalcanti de Lima; Alexandre Sérgio Silva; João Carlos Lima Rodrigues Pita; Nadjeanny Ingrid Galdino Gomes; Elisama Araújo de Sena; Rhayra Priscila Moraes Nobrega; João Otávio Scarano Alcântara; Julie Hanna Fontes de Souza; Glêbia Alexa Cardoso; José Luiz de Brito Alves; Maria da Conceição Rodrigues Gonçalves Journal: Diabetes Metab Syndr Obes Date: 2021-02-04 Impact factor: 3.168