Ji Han1, Chunyang Zhao1, Jiayi Cai2, Yu Liang3. 1. Department of Pharmacy, The First Affiliated Hospital of China Medical University, No.155 Nanjing Street, Shenyang, China; College of Pharmaceutical Science, China Medical University, No.77 Puhe Road, Shenyang, China. 2. College of Pharmaceutical Science, China Medical University, No.77 Puhe Road, Shenyang, China. 3. Department of Pharmacy, The First Affiliated Hospital of China Medical University, No.155 Nanjing Street, Shenyang, China; College of Pharmaceutical Science, China Medical University, No.77 Puhe Road, Shenyang, China. Electronic address: liangyucmu1@163.com.
Abstract
BACKGROUND: Vitamins are commonly used in the prevention of major cardiovascular disease. However, the efficacy and optimum choice remain controversial. OBJECTIVE: To compare and rank the relative efficacy among all available vitamin preparations for cardiovascular disease through a network meta-analysis. METHODS: Eligible studies were identified by searching PubMed, Embase, Medline, Cochrane library and Web of Science for randomized controlled trials. A random effects model was applied within a frequentist framework. RESULTS: Forty-two articles (45 comparisons, 384,248 participants), including nine vitamin interventions, were identified. Vitamin D had the highest probability of being ranked best in effectiveness (0.84 [0.72, 0.98]) on prevention of cardiovascular events. With regard to reducing death of cardiovascular disease rate, vitamin E was considered better efficacy. CONCLUSIONS: Vitamin B, D and E could reduce the incidence of cardiovascular events to varying degrees. At the same time, the combination of vitamins can not show improvement on the efficacy.
BACKGROUND: Vitamins are commonly used in the prevention of major cardiovascular disease. However, the efficacy and optimum choice remain controversial. OBJECTIVE: To compare and rank the relative efficacy among all available vitamin preparations for cardiovascular disease through a network meta-analysis. METHODS: Eligible studies were identified by searching PubMed, Embase, Medline, Cochrane library and Web of Science for randomized controlled trials. A random effects model was applied within a frequentist framework. RESULTS: Forty-two articles (45 comparisons, 384,248 participants), including nine vitamin interventions, were identified. Vitamin D had the highest probability of being ranked best in effectiveness (0.84 [0.72, 0.98]) on prevention of cardiovascular events. With regard to reducing death of cardiovascular disease rate, vitamin E was considered better efficacy. CONCLUSIONS:Vitamin B, D and E could reduce the incidence of cardiovascular events to varying degrees. At the same time, the combination of vitamins can not show improvement on the efficacy.