Literature DB >> 32379587

Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.

Ayad A Al-Hamashi1, Krystal Diaz1, Rong Huang1.   

Abstract

Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent posttransitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and how PRMT-mediated non-histone arginine methylation modulates various diseases. Additionally, we highlight the most recent clinical studies for several PRMT inhibitors. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  PRMT; PRMT inhibitor; arginine methylation; cancer; epigenetic modifications; non-histone protein

Mesh：

Substances：

Year:  2020        PMID： 32379587      PMCID： PMC7529871          DOI： 10.2174/1389203721666200507091952

Source DB:  PubMed          Journal:  Curr Protein Pept Sci        ISSN： 1389-2037            Impact factor:   3.272


  120 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-05       Impact factor: 11.205

Review 2.  Biochemistry and regulation of the protein arginine methyltransferases (PRMTs).

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3.  The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity.

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Review 4.  Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

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5.  Arginine methylation of the nuclear poly(a) binding protein weakens the interaction with its nuclear import receptor, transportin.

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Journal:  J Biol Chem       Date:  2011-08-01       Impact factor: 5.157

6.  Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.

Authors:  Shinsuke Mizutani; Tatsushi Yoshida; Xinyang Zhao; Stephen D Nimer; Masafumi Taniwaki; Tsukasa Okuda
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7.  Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family.

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Journal:  J Cell Sci       Date:  2009-02-10       Impact factor: 5.285

8.  Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats.

Authors:  Hiroaki Iwasaki
Journal:  Life Sci       Date:  2009-05-23       Impact factor: 5.037

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Journal:  EMBO Mol Med       Date:  2012-10-15       Impact factor: 12.137
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  4 in total

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Journal:  Biomed Rep       Date:  2022-09-16

2.  Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5.

Authors:  Ayad A Al-Hamashi; Dongxing Chen; Youchao Deng; Guangping Dong; Rong Huang
Journal:  Acta Pharm Sin B       Date:  2020-10-16       Impact factor: 14.903

Review 3.  Posttranslational control of lipogenesis in the tumor microenvironment.

Authors:  Yahui Zhu; Xingrong Lin; Xiaojun Zhou; Edward V Prochownik; Fubing Wang; Youjun Li
Journal:  J Hematol Oncol       Date:  2022-08-29       Impact factor: 23.168

4.  Arginine Depletion in Human Cancers.

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Journal:  Cancers (Basel)       Date:  2021-12-14       Impact factor: 6.639
  4 in total

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