Literature DB >> 32378647

Treat 2019 novel coronavirus (COVID-19) with IL-6 inhibitor: Are we already that far?

Yuanyuan Zhang1, Yanyan Zhong1, Lin Pan1, Jing Dong1.   

Abstract

The world is in the midst of the coronavirus disease 2019 (COVID-19) pandemic. Interleukin 6 (IL-6) inhibitor (tocilizumab) had been suggested for the treatment of acute respiratory distress syndrome (ARDS) patients based on the concept of "cytokine storm" in COVID-19. However, we still lack reliable studies to verify "cytokine storm" in COVID-19 pneumonia. Furthermore, IL-6 inhibitor has potential hazards of inducing infectious diseases. The efficacy of IL-6 monoclonal antibody-directed therapy remains to be fully evaluated.

Entities:  

Keywords:  coronavirus; cytokine storm; pneumonia; tocilizumab

Year:  2020        PMID： 32378647     DOI： 10.5582/ddt.2020.03006

Source DB:  PubMed          Journal:  Drug Discov Ther        ISSN： 1881-7831


  17 in total

1.  The Probable Protective Effect of Photobiomodulation on the Inflammation of the Airway and Lung in COVID-19 Treatment: A Preclinical and Clinical Meta-Analysis.

Authors:  Hanieh Raji; Babak Arjmand; Fakher Rahim
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

Review 2.  Two Years into the COVID-19 Pandemic: Lessons Learned.

Authors:  Severino Jefferson Ribeiro da Silva; Jessica Catarine Frutuoso do Nascimento; Renata Pessôa Germano Mendes; Klarissa Miranda Guarines; Caroline Targino Alves da Silva; Poliana Gomes da Silva; Jurandy Júnior Ferraz de Magalhães; Justin R J Vigar; Abelardo Silva-Júnior; Alain Kohl; Keith Pardee; Lindomar Pena
Journal:  ACS Infect Dis       Date:  2022-08-08       Impact factor: 5.578

3.  Serum Level of 4-Hydroxynonenal in Community-Acquired Pneumonia: A Potential Biomarker for Severity and Prognosis.

Authors:  Ya-Lin Jiang; Hong-Yan Liu; Min-Min Tang; Jia-Yi Cheng; Hui Zhao; Lin Fu
Journal:  Front Med (Lausanne)       Date:  2022-06-17

Review 4.  Laboratory tests for the detection of SARS-CoV-2 infection: basic principles and examples.

Authors:  Khaled R Alkharsah
Journal:  Ger Med Sci       Date:  2021-05-27

5.  First COVID-19 sub-intensive respiratory unit in Europe: the Italian experience.

Authors:  Sonia Henchi; Clara Benedetta Conti; Nicolò Vanoni; Alice Claudia Repossi; Giuseppe Cipolla; Mirko Marra; Elena Esposti; Michela Fiini; Irene Raimondi Cominesi; Monica Crepaldi; Mariano Scozzafava
Journal:  Multidiscip Respir Med       Date:  2020-06-23

Review 6.  Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label Drugs.

Authors:  Stefania Scala; Roberto Pacelli
Journal:  Front Immunol       Date:  2020-05-27       Impact factor: 7.561

7.  Early use of low dose tocilizumab in patients with COVID-19: A retrospective cohort study with a complete follow-up.

Authors:  Nicola De Rossi; Cristina Scarpazza; Chiara Filippini; Cinzia Cordioli; Sarah Rasia; Chiara Rosa Mancinelli; Damiano Rizzoni; Giuseppe Romanelli; Stefania Cossi; Nereo Vettoretto; Sergio Bove; Silvano Manfredini; Eva Andrea Beindorf; Carlo Mosca; Vittorio Scipione; Gigliola Flamminio; Elena Albini Albini; Paola Giansiracusa; Ruggero Capra
Journal:  EClinicalMedicine       Date:  2020-07-17

8.  Early use of tocilizumab in the prevention of adult respiratory failure in SARS-CoV-2 infections and the utilization of interleukin-6 levels in the management.

Authors:  Suresh J Antony; Michelle A Davis; Monique G Davis; Nouf K Almaghlouth; Roberto Guevara; Fahad Omar; Fernando Del Rey; Ali Hassan; Muhammad U Arian; Nishaal Antony; Bharat V Prakash
Journal:  J Med Virol       Date:  2020-07-15       Impact factor: 20.693

9.  Management of leprosy patients in the era of COVID-19.

Authors:  Ayman Abdelmaksoud; Sunil Kumar Gupta
Journal:  Dermatol Ther       Date:  2020-06-24       Impact factor: 3.858

Review 10.  A 21st Century Evil: Immunopathology and New Therapies of COVID-19.

Authors:  Taylon Felipe Silva; Fernanda Tomiotto-Pellissier; Raquel Arruda Sanfelice; Manoela Daiele Gonçalves; Bruna Taciane da Silva Bortoleti; Mariana Barbosa Detoni; Ana Carolina Jacob Rodrigues; Amanda Cristina Machado Carloto; Virgínia Márcia Concato; Elaine da Silva Siqueira; Idessania Nazareth Costa; Wander Rogério Pavanelli; Ivete Conchon-Costa; Milena Menegazzo Miranda-Sapla
Journal:  Front Immunol       Date:  2020-10-27       Impact factor: 7.561
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