Literature DB >> 32376035

Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures.

Quynh-Anh Nguyen1, Prannath Moolchand1, Ivan Soltesz2.   

Abstract

Epilepsy is a neurological disorder characterized by recurrent seizures, where abnormal electrical activity begins in a local brain area and propagates before terminating. In a recent study, Liou and colleagues used multiscale computational modeling to gain mechanistic insights into clinical seizure dynamics based on cellular-level biophysical properties.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GABA; computational modeling; epilepsy; excitation; inhibition; seizure dynamics

Mesh：

Year:  2020        PMID： 32376035      PMCID： PMC7665900          DOI： 10.1016/j.tins.2020.04.006

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  6 in total

Review 1.  Resolving the Micro-Macro Disconnect to Address Core Features of Seizure Networks.

Authors:  Jordan S Farrell; Quynh-Anh Nguyen; Ivan Soltesz
Journal:  Neuron       Date:  2019-03-20       Impact factor: 17.173

2.  The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states. II. Network and glial dynamics.

Authors:  Ghanim Ullah; John R Cressman; Ernest Barreto; Steven J Schiff
Journal:  J Comput Neurosci       Date:  2008-12-13       Impact factor: 1.621

3.  On the nature of seizure dynamics.

Authors:  Viktor K Jirsa; William C Stacey; Pascale P Quilichini; Anton I Ivanov; Christophe Bernard
Journal:  Brain       Date:  2014-06-11       Impact factor: 13.501

4.  A model for focal seizure onset, propagation, evolution, and progression.

Authors:  Jyun-You Liou; Elliot H Smith; Lisa M Bateman; Samuel L Bruce; Guy M McKhann; Robert R Goodman; Ronald G Emerson; Catherine A Schevon; L F Abbott
Journal:  Elife       Date:  2020-03-23       Impact factor: 8.140

5.  The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics.

Authors:  John R Cressman; Ghanim Ullah; Jokubas Ziburkus; Steven J Schiff; Ernest Barreto
Journal:  J Comput Neurosci       Date:  2009-01-24       Impact factor: 1.621

6.  Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model.

Authors:  Anatoly Buchin; Anton Chizhov; Gilles Huberfeld; Richard Miles; Boris S Gutkin
Journal:  J Neurosci       Date:  2016-11-16       Impact factor: 6.167
  6 in total
  1 in total

1.  Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.

Authors:  Elliot H Smith; Jyun-You Liou; Edward M Merricks; Tyler Davis; Kyle Thomson; Bradley Greger; Paul House; Ronald G Emerson; Robert Goodman; Guy M McKhann; Sameer Sheth; Catherine Schevon; John D Rolston
Journal:  Elife       Date:  2022-01-20       Impact factor: 8.713
  1 in total

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