Nicolae Gica1,2, Anca Maria Panaitescu1,2, George Iancu3,4, Radu Botezatu1,2, Gheorghe Peltecu1,2, Corina Gica2. 1. "Carol Davila" University of Medicine and Pharmacy, Department of Obstetrics and Gynecology, Bucharest, Romania. 2. Gynaecology Department - Filantropia Clinical Hospital, Bucharest, Romania. 3. "Carol Davila" University of Medicine and Pharmacy, Department of Obstetrics and Gynecology, Bucharest, Romania. george.iancu@spitalulfilantropia.ro. 4. Gynaecology Department - Filantropia Clinical Hospital, Bucharest, Romania. george.iancu@spitalulfilantropia.ro.
Abstract
OBJECTIVES: Our study evaluates if the use of biological markers can predict the infertility in women with non-obstructive endometriosis. MATERIAL AND METHODS: Two prospective, non-randomised studies were conducted to identify if CA-125, IL-6 and IL-8 can be used as predictive markers for infertility in women with non-obstructive endometriosis. Peripheral levels of CA-125, IL-6 and IL-8 were measured before laparoscopy in all patients. RESULTS: We found a total number of 152 patients with non-obstructive endometriosis, we divided them in two groups: fertile and infertile women. There was a statistically significant difference of the mean of CA-125 values between the two groups (p = 0.00). The patients with infertility had a significantly higher IL-6 serum values than the fertile patients (p = 0.00). Regarding the IL-8 serum values, there was no statistically significant difference between the two groups fertile vs infertile, (p = 0.06). CONCLUSIONS: The elevated serum levels of CA-125 and IL-6 was associated with an increased probability of being diagnosed with infertility. The IL-8 had no value in predicting infertility associated with non-obstructive endometriosis.
OBJECTIVES: Our study evaluates if the use of biological markers can predict the infertility in women with non-obstructive endometriosis. MATERIAL AND METHODS: Two prospective, non-randomised studies were conducted to identify if CA-125, IL-6 and IL-8 can be used as predictive markers for infertility in women with non-obstructive endometriosis. Peripheral levels of CA-125, IL-6 and IL-8 were measured before laparoscopy in all patients. RESULTS: We found a total number of 152 patients with non-obstructive endometriosis, we divided them in two groups: fertile and infertilewomen. There was a statistically significant difference of the mean of CA-125 values between the two groups (p = 0.00). The patients with infertility had a significantly higher IL-6 serum values than the fertile patients (p = 0.00). Regarding the IL-8 serum values, there was no statistically significant difference between the two groups fertile vs infertile, (p = 0.06). CONCLUSIONS: The elevated serum levels of CA-125 and IL-6 was associated with an increased probability of being diagnosed with infertility. The IL-8 had no value in predicting infertility associated with non-obstructive endometriosis.