Beatrice Benatti1, Silvia Ferrari1, Benedetta Grancini1, Nicolaja Girone1, Matteo Briguglio2, Donatella Marazziti3, Federico Mucci3, Liliana Dell'Osso3, Orsola Gambini4,5, Benedetta Demartini4,5, Antonio Tundo6, Roberta Necci6, Domenico De Berardis7,8, Roberta Galentino2, Sara De Michele2, Umberto Albert9, Sylvia Rigardetto10, Giuseppe Maina10, Giacomo Grassi11, Stefano Pallanti12, Andrea Amerio13,14,15, Mario Amore13,14, Alberto Priori4,5, Domenico Servello2, Caterina Viganò1, Monica Bosi1, Anna Colombo1, Mauro Porta2, Bernardo Dell'Osso1,5,12,16. 1. Luigi Sacco University Hospital, Psychiatry 2 Unit, University of Milan, Milan, Italy. 2. IRCCS Orthopedic Institute Galeazzi, Department of Functional Neurosurgery, Tourette Center, Milan, Italy. 3. Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy. 4. Department of Health Sciences, University of Milan, Milan, Italy. 5. "Aldo Ravelli" Center for Nanotechnology and Neurostimulation, University of Milan, Milan, Italy. 6. Institute of Psychopathology, Rome, Italy. 7. NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", Teramo, Italy. 8. Department of Neuroscience, Imaging and Clinical Science, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy. 9. Dipartimento Universitario Clinico di Scienze Mediche Chirurgiche e della Salute, Università degli Studi di Trieste, Trieste, Italy; SC Clinica Psichiatrica, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Trieste, Italy. 10. San Luigi Gonzaga Hospital, University of Turin, Turin, Italy. 11. Brain Center Firenze, Florence, Italy. 12. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. 13. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Genoa, Italy. 14. IRCCS Ospedale Policlinico San Martino, Genoa, Italy. 15. Mood Disorders Program, Tufts Medical Center, Boston, Massachusetts, USA. 16. Centro per lo studio dei meccanismi molecolari alla base delle patologie neuro-psico-geriatriche", University of Milan, Milan, Italy.
Abstract
BACKGROUND: Obsessive-compulsive disorder (OCD) and tic disorder (TD) represent highly disabling, chronic and often comorbid psychiatric conditions. While recent studies showed a high risk of suicide for patients with OCD, little is known about those patients with comorbid TD (OCTD). Aim of this study was to characterize suicidal behaviors among patients with OCD and OCTD. METHODS: Three hundred and thirteen outpatients with OCD (n = 157) and OCTD (n = 156) were recruited from nine different psychiatric Italian departments and assessed using an ad-hoc developed questionnaire investigating, among other domains, suicide attempt (SA) and ideation (SI). The sample was divided into four subgroups: OCD with SA (OCD-SA), OCD without SA (OCD-noSA), OCTD with SA (OCTD-SA), and OCTD without SA (OCTD-noSA). RESULTS: No differences between groups were found in terms of SI, while SA rates were significantly higher in patients with OCTD compared to patients with OCD. OCTD-SA group showed a significant male prevalence and higher unemployment rates compared to OCD-SA and OCD-noSA sample. Both OCTD-groups showed an earlier age of psychiatric comorbidity onset (other than TD) compared to the OCD-SA sample. Moreover, patients with OCTD-SA showed higher rates of other psychiatric comorbidities and positive psychiatric family history compared to the OCD-SA group and to the OCD-noSA groups. OCTD-SA and OCD-SA samples showed higher rates of antipsychotics therapies and treatment resistance compared to OCD-noSA groups. CONCLUSIONS: Patients with OCTD vs with OCD showed a significantly higher rate of SA with no differences in SI. In particular, OCTD-SA group showed different unfavorable epidemiological and clinical features which need to be confirmed in future prospective studies.
BACKGROUND: Obsessive-compulsive disorder (OCD) and tic disorder (TD) represent highly disabling, chronic and often comorbid psychiatric conditions. While recent studies showed a high risk of suicide for patients with OCD, little is known about those patients with comorbid TD (OCTD). Aim of this study was to characterize suicidal behaviors among patients with OCD and OCTD. METHODS: Three hundred and thirteen outpatients with OCD (n = 157) and OCTD (n = 156) were recruited from nine different psychiatric Italian departments and assessed using an ad-hoc developed questionnaire investigating, among other domains, suicide attempt (SA) and ideation (SI). The sample was divided into four subgroups: OCD with SA (OCD-SA), OCD without SA (OCD-noSA), OCTD with SA (OCTD-SA), and OCTD without SA (OCTD-noSA). RESULTS: No differences between groups were found in terms of SI, while SA rates were significantly higher in patients with OCTD compared to patients with OCD. OCTD-SA group showed a significant male prevalence and higher unemployment rates compared to OCD-SA and OCD-noSA sample. Both OCTD-groups showed an earlier age of psychiatric comorbidity onset (other than TD) compared to the OCD-SA sample. Moreover, patients with OCTD-SA showed higher rates of other psychiatric comorbidities and positive psychiatric family history compared to the OCD-SA group and to the OCD-noSA groups. OCTD-SA and OCD-SA samples showed higher rates of antipsychotics therapies and treatment resistance compared to OCD-noSA groups. CONCLUSIONS: Patients with OCTD vs with OCD showed a significantly higher rate of SA with no differences in SI. In particular, OCTD-SA group showed different unfavorable epidemiological and clinical features which need to be confirmed in future prospective studies.
Authors: Vahid Khosravani; Seyed Mehdi Samimi Ardestani; Farangis Sharifi Bastan; Dean McKay; Gordon J G Asmundson Journal: Clin Psychol Psychother Date: 2021-05-05