Literature DB >> 32371565

Lipid sensing tips the balance for a key cholesterol synthesis enzyme.

Ngee Kiat Chua1, Andrew J Brown2.   

Abstract

Entities:  

Year:  2020        PMID： 32371565      PMCID： PMC7604718          DOI： 10.1194/jlr.ILR120000801

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


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  4 in total

1.  Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.

Authors:  Ngee Kiat Chua; Gene Hart-Smith; Andrew J Brown
Journal:  J Biol Chem       Date:  2019-04-02       Impact factor: 5.157

2.  Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.

Authors:  Saloni Gill; Julian Stevenson; Ika Kristiana; Andrew J Brown
Journal:  Cell Metab       Date:  2011-03-02       Impact factor: 27.287

3.  A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.

Authors:  Ngee Kiat Chua; Vicky Howe; Nidhi Jatana; Lipi Thukral; Andrew J Brown
Journal:  J Biol Chem       Date:  2017-09-27       Impact factor: 5.157

4.  A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.

Authors:  Hiromasa Yoshioka; Hudson W Coates; Ngee Kiat Chua; Yuichi Hashimoto; Andrew J Brown; Kenji Ohgane
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-13       Impact factor: 11.205
  4 in total

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