Literature DB >> 32371415

Acute airway compromise and coagulopathy: a rare presentation of acquired haemophilia A.

William Byron Howden1,2, Jonathan Kam2, Nicholas Leith2, Shashinder Singh2.   

Abstract

Acquired haemophilia A is a rare but important diagnosis, carrying a mortality rate of 22%. Life-threatening sequalae of this diagnosis includes airway compromise, which can rapidly lead to demise of the patient if left untreated. Our case examines an 80-year-old man presenting with a supraglottic haematoma resulting from acquired haemophilia A causing airway compromise and necessitating definitive airway control. A review of current understanding and management of the disease is also ddiscussed. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  adult intensive care; ear, nose and throat/otolaryngology; haematology (incl blood transfusion)

Mesh:

Substances:

Year:  2020        PMID: 32371415      PMCID: PMC7222884          DOI: 10.1136/bcr-2019-233345

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  18 in total

1.  A 54-year-old woman with acute airway obstruction.

Authors:  Mark V Hendricks; Linda K Hendricks; W Bruce Davis
Journal:  Chest       Date:  2002-07       Impact factor: 9.410

2.  Upper airway obstruction caused by acquired inhibitor to factor VIII.

Authors:  G M Joynt; N W Wickham; R J Young; C D Gomersall
Journal:  Anaesthesia       Date:  1996-07       Impact factor: 6.955

3.  Acquired haemophilia secondary to ivabradine presenting with acute respiratory distress syndrome.

Authors:  Moussa Albert Riachy; Fadi Nasr; Rabih Azar
Journal:  BMJ Case Rep       Date:  2012-04-04

Review 4.  Acquired hemophilia A: Updated review of evidence and treatment guidance.

Authors:  Rebecca Kruse-Jarres; Christine L Kempton; Francesco Baudo; Peter W Collins; Paul Knoebl; Cindy A Leissinger; Andreas Tiede; Craig M Kessler
Journal:  Am J Hematol       Date:  2017-06-05       Impact factor: 10.047

5.  Tranexamic acid as adjunct therapy to bypassing agents in haemophilia A patients with inhibitors.

Authors:  H T T Tran; B Sørensen; C J Rea; S Bjørnsen; T Ueland; A H Pripp; G E Tjønnfjord; P A Holme
Journal:  Haemophilia       Date:  2013-11-19       Impact factor: 4.287

Review 6.  Acquired factor VIII inhibitors: pathophysiology and treatment.

Authors:  Alice D Ma; Daniel Carrizosa
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2006

7.  Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2).

Authors:  P Knoebl; P Marco; F Baudo; P Collins; A Huth-Kühne; L Nemes; F Pellegrini; L Tengborn; H Lévesque
Journal:  J Thromb Haemost       Date:  2012-04       Impact factor: 5.824

8.  Acquired haemophilia caused by non-haemophilic factor VIII gene variants.

Authors:  Andreas Tiede; Roswith Eisert; Andreas Czwalinna; Wolfgang Miesbach; Inge Scharrer; Arnold Ganser
Journal:  Ann Hematol       Date:  2010-01-07       Impact factor: 3.673

9.  Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A.

Authors:  A-M Hvas; H T Sørensen; L Norengaard; K Christiansen; J Ingerslev; B Sørensen
Journal:  J Thromb Haemost       Date:  2007-09-06       Impact factor: 5.824

Review 10.  The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis.

Authors:  Rhonda L Bitting; Stephen Bent; Yongmei Li; Jeffrey Kohlwes
Journal:  Blood Coagul Fibrinolysis       Date:  2009-10       Impact factor: 1.276

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