Kanhatai Chiengthong1,2, Wisit Cheungpasitporn3, Charat Thongprayoon4, Ploypin Lertjitbanjong5, Liam D Cato6, Tarun Bathini7, Patompong Ungprasert8, Michael A Mao9, Ronpichai Chokesuwattanaskul2,10. 1. Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand. 2. King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. 3. Department of Medicine, University of Mississippi Medical Center, Mississippi, Jackson. 4. Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota. 5. Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York. 6. University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. 7. Department of Internal Medicine, University of Arizona, Tucson, Arizona. 8. Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. 9. Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida. 10. Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Abstract
OBJECTIVE: Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT. METHODS: A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Eligible studies were required to1 be clinical trials or observational studies (cohort, case-control, or cross-sectional studies);2 provide data to calculate the odds ratios (OR) of GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 95% confidence interval (CI) were estimated using random-effects meta-analysis through the Comprehensive Meta-Analysis 3.3 software. RESULTS: In total, 8 observational studies consisting of 1335 HSCT patients were enrolled in this systematic review. Overall, there was no significant association between vitamin D deficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no significant association between vitamin D deficiency and chronic GVHD (OR = 1.75, 95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test were performed and showed no publication bias. CONCLUSION: There is not a statistically significant association between vitamin D deficiency and neither acute nor chronic GVHD.
OBJECTIVE:Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT. METHODS: A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Eligible studies were required to1 be clinical trials or observational studies (cohort, case-control, or cross-sectional studies);2 provide data to calculate the odds ratios (OR) of GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 95% confidence interval (CI) were estimated using random-effects meta-analysis through the Comprehensive Meta-Analysis 3.3 software. RESULTS: In total, 8 observational studies consisting of 1335 HSCT patients were enrolled in this systematic review. Overall, there was no significant association between vitamin Ddeficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no significant association between vitamin Ddeficiency and chronic GVHD (OR = 1.75, 95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test were performed and showed no publication bias. CONCLUSION: There is not a statistically significant association between vitamin D deficiency and neither acute nor chronic GVHD.
Authors: Carina Matos; Katrin Peter; Laura Weich; Alice Peuker; Gabriele Schoenhammer; Tobias Roider; Sakhila Ghimire; Nathalie Babl; Sonja Decking; Martina Güllstorf; Nicolaus Kröger; Kathrin Hammon; Wolfgang Herr; Klaus Stark; Iris M Heid; Kathrin Renner; Ernst Holler; Marina Kreutz Journal: Front Immunol Date: 2022-01-04 Impact factor: 7.561