Yuto Uchida1,2, Hirohito Kan3, Keita Sakurai4, Shohei Inui5, Susumu Kobayashi6, Yoshihiro Akagawa6, Kazuyoshi Shibuya6, Yoshino Ueki7, Noriyuki Matsukawa1. 1. Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. 2. Department of Neurology, Toyokawa City Hospital, Aichi, Japan. 3. Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan. 4. Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan. 5. Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 6. Department of Radiology, Toyokawa City Hospital, Aichi, Japan. 7. Department of Rehabilitation Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Abstract
OBJECTIVE: The objective of this study was to assess the relationship between nigrostriatal magnetic susceptibility and dopamine transporter abnormality and their associations with behavioral and cognitive impairments in patients with Parkinson's disease (PD). METHODS: For this case-control study, we enrolled 41 patients with PD and 20 age-matched healthy controls. All participants underwent global physical and cognitive assessments, 3-Tesla brain magnetic resonance imaging including quantitative susceptibility mapping (QSM; iron deposition measure), and 123 I-N-v-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane single-photon emission computed tomography (dopamine transporter measure). We subdivided the striatum into the putamen, caudate nucleus, and nucleus accumbens and measured the nigrostriatal QSM values and dopamine transporter-specific binding ratios using an atlas-based approach. RESULTS: The patients with PD had higher QSM values in the substantia nigra and subdivisions of the striatum than did the healthy controls. The striatal dopamine transporter-specific binding ratios were not correlated with the QSM values of the substantia nigra but were inversely correlated with those of the striatum (putamen, r = -0.478, P = 0.009; caudate nucleus, r = -0.462, P = 0.011). The QSM values of the putamen were positively correlated with motor parkinsonism scores (Movement Disorder Society Unified Parkinson's Disease Rating Scale, r = 0.505, P = 0.003), and those of the caudate nucleus were negatively correlated with cognitive impairment scores (Montreal Cognitive Assessment, r = -0.525, P < 0.001). CONCLUSIONS: This study showed that striatal iron accumulations were correlated with dopaminergic deficits and neurophysiological signs in patients with PD, highlighting the potential of QSM as an auxiliary biomarker for parkinsonism and cognitive dysfunction.
OBJECTIVE: The objective of this study was to assess the relationship between nigrostriatal magnetic susceptibility and dopamine transporter abnormality and their associations with behavioral and cognitive impairments in patients with Parkinson's disease (PD). METHODS: For this case-control study, we enrolled 41 patients with PD and 20 age-matched healthy controls. All participants underwent global physical and cognitive assessments, 3-Tesla brain magnetic resonance imaging including quantitative susceptibility mapping (QSM; iron deposition measure), and 123 I-N-v-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane single-photon emission computed tomography (dopamine transporter measure). We subdivided the striatum into the putamen, caudate nucleus, and nucleus accumbens and measured the nigrostriatal QSM values and dopamine transporter-specific binding ratios using an atlas-based approach. RESULTS: The patients with PD had higher QSM values in the substantia nigra and subdivisions of the striatum than did the healthy controls. The striatal dopamine transporter-specific binding ratios were not correlated with the QSM values of the substantia nigra but were inversely correlated with those of the striatum (putamen, r = -0.478, P = 0.009; caudate nucleus, r = -0.462, P = 0.011). The QSM values of the putamen were positively correlated with motor parkinsonism scores (Movement Disorder Society Unified Parkinson's Disease Rating Scale, r = 0.505, P = 0.003), and those of the caudate nucleus were negatively correlated with cognitive impairment scores (Montreal Cognitive Assessment, r = -0.525, P < 0.001). CONCLUSIONS: This study showed that striatal iron accumulations were correlated with dopaminergic deficits and neurophysiological signs in patients with PD, highlighting the potential of QSM as an auxiliary biomarker for parkinsonism and cognitive dysfunction.
Authors: Gregory Brown; Guangwei Du; Elana Farace; Mechelle M Lewis; Paul J Eslinger; James McInerney; Lan Kong; Runze Li; Xuemei Huang; Sol De Jesus Journal: J Parkinsons Dis Date: 2022 Impact factor: 5.520
Authors: Yun Jung Bae; Jong-Min Kim; Byung Se Choi; Yoo Sung Song; Yoonho Nam; Se Jin Cho; Jae Hyoung Kim; Sang Eun Kim Journal: Taehan Yongsang Uihakhoe Chi Date: 2022-05-25