Eric M Wohlford1, Luisa N Borrell2, Jennifer R Elhawary1, Brian Plotkin1, Sam S Oh1, Thomas J Nuckton1, Celeste Eng1, Sandra Salazar1, Michael A LeNoir3, Kelley Meade4, Harold J Farber5, Denise Serebrisky6, Emerita Brigino-Buenaventura7, William Rodriguez-Cintron8, Rajesh Kumar9, Shannon Thyne10, Max A Seibold11, José R Rodríguez-Santana12, Esteban G Burchard1,13. 1. Department of Medicine, University of California, San Francisco, CA, United States of America. 2. Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY, United States of America. 3. Bay Area Pediatrics, Oakland, CA, United States of America. 4. Children's Hospital and Research Center Oakland, Oakland, CA, United States of America. 5. Department of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, United States of America. 6. Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY, United States of America. 7. Department of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, CA, United States of America. 8. Veterans Caribbean Health Care System, San Juan, Puerto Rico, United States of America. 9. The Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States of America. 10. Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States of America. 11. National Jewish Health, Denver, CO, United States of America. 12. Centro de Neumologia Pediátrica, Caguas, Puerto Rico, United States of America. 13. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, United States of America.
Abstract
RATIONALE: Severe early-life respiratory illnesses, particularly those caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV), are strongly associated with the development of asthma in children. Puerto Rican children in particular have a strikingly high asthma burden. However, prior studies of the potential associations between early-life respiratory illnesses and asthma in Puerto Rican and other minority populations have been limited. OBJECTIVES: We sought to determine whether early-life respiratory illness was associated with asthma in Puerto Rican, Mexican American, and African American children. METHODS: Using a logistic regression analysis, we examined the association between early-life respiratory illnesses (report of upper respiratory infection (URI), pneumonia, bronchitis, and bronchiolitis/RSV) within the first two years of life and physician-diagnosed asthma after the age of two in a large cohort of Puerto Rican, Mexican American, and African American children. MEASUREMENTS AND MAIN RESULTS: While early-life respiratory illnesses were associated with greater asthma odds in Puerto Ricans, Mexican Americans, and African Americans, these associations were stronger among Puerto Rican children. Specifically, in Puerto Ricans, the odds was 6.15 (95% CI: 4.21-9.05) if the child reported at least one of the following respiratory illness: URI, pneumonia, bronchitis or bronchiolitis. The odds were also higher in Puerto Ricans when considering these conditions separately. CONCLUSIONS: We observed population-specific associations between early-life respiratory illnesses and asthma, which were especially significant and stronger in Puerto Ricans. Taken together with the known high burden of RSV in Puerto Rico, our results may help explain the high burden of asthma in Puerto Ricans.
RATIONALE: Severe early-life respiratory illnesses, particularly those caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV), are strongly associated with the development of asthma in children. Puerto Rican children in particular have a strikingly high asthma burden. However, prior studies of the potential associations between early-life respiratory illnesses and asthma in Puerto Rican and other minority populations have been limited. OBJECTIVES: We sought to determine whether early-life respiratory illness was associated with asthma in Puerto Rican, Mexican American, and African American children. METHODS: Using a logistic regression analysis, we examined the association between early-life respiratory illnesses (report of upper respiratory infection (URI), pneumonia, bronchitis, and bronchiolitis/RSV) within the first two years of life and physician-diagnosed asthma after the age of two in a large cohort of Puerto Rican, Mexican American, and African American children. MEASUREMENTS AND MAIN RESULTS: While early-life respiratory illnesses were associated with greater asthma odds in Puerto Ricans, Mexican Americans, and African Americans, these associations were stronger among Puerto Rican children. Specifically, in Puerto Ricans, the odds was 6.15 (95% CI: 4.21-9.05) if the child reported at least one of the following respiratory illness: URI, pneumonia, bronchitis or bronchiolitis. The odds were also higher in Puerto Ricans when considering these conditions separately. CONCLUSIONS: We observed population-specific associations between early-life respiratory illnesses and asthma, which were especially significant and stronger in Puerto Ricans. Taken together with the known high burden of RSV in Puerto Rico, our results may help explain the high burden of asthma in Puerto Ricans.
Authors: John Heintzman; David Ezekiel-Herrera; Steffani R Bailey; Arvin Garg; Jennifer Lucas; Shakira Suglia; Stuart Cowburn; Jon Puro; Miguel Marino Journal: J Asthma Date: 2020-12-18 Impact factor: 2.515
Authors: Karl Heilbron; Sahar V Mozaffari; Vladimir Vacic; Peng Yue; Wei Wang; Jingchunzi Shi; Adrian M Jubb; Steven J Pitts; Xin Wang Journal: J Pathol Date: 2021-04-09 Impact factor: 7.996