Maria Makarova1, Dylan M Owen2. 1. Institute of Immunology and Immunotherapy, Department of Mathematics and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK. 2. Institute of Immunology and Immunotherapy, Department of Mathematics and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK. d.owen@bham.ac.uk.