Ryota Tanaka1, Kenjiro Kimura2, Shinpei Eguchi3, Jun Tauchi3, Masatune Shibutani1, Hiroji Shinkawa3, G O Ohira3, Sadaaki Yamazoe3, Shogo Tanaka3, Ryosuke Amano3, Hiroaki Tanaka1, Masakazu Yashiro1,4,5, Shoji Kubo3, Masaichi Ohira1. 1. Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. 2. Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan kenjiro@med.osaka-cu.ac.jp. 3. Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. 4. Molecular Oncology and Therapeutics, Osaka City University Graduate School of Medicine, Osaka, Japan. 5. Cancer Center for Translational Research, Osaka City University Graduate School of Medicine, Osaka, Japan.
Abstract
BACKGROUND/AIM: This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8+ tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8+ TILs in biliary tract cancers (BTCs). PATIENTS AND METHODS: A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. CD8+ TILs were identified by immunohistochemical staining. RESULTS: The overall survival (OS) and recurrence-free survival (RFS) of patients with high NLR were shorter than those with low NLR. The OS and RFS of patients with high CD8+ TILs were longer than those with low CD8+ TILs. Preoperative NLR and CD8+ TILs were negatively correlated. CONCLUSION: NLR and CD8+ TILs were associated with OS and RFS in BTCs. NLR can predict CD8+ TILs infiltrating the cancer microenvironment. Copyright
BACKGROUND/AIM: This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8+ tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8+ TILs in biliary tract cancers (BTCs). PATIENTS AND METHODS: A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. CD8+ TILs were identified by immunohistochemical staining. RESULTS: The overall survival (OS) and recurrence-free survival (RFS) of patients with high NLR were shorter than those with low NLR. The OS and RFS of patients with high CD8+ TILs were longer than those with low CD8+ TILs. Preoperative NLR and CD8+ TILs were negatively correlated. CONCLUSION: NLR and CD8+ TILs were associated with OS and RFS in BTCs. NLR can predict CD8+ TILs infiltrating the cancer microenvironment. Copyright
Authors: Stephanie Roessler; Benjamin Goeppert; Alphonse Charbel; Luca Tavernar; Thomas Albrecht; Fritz Brinkmann; Joanne Verheij; Eva Roos; Monika Nadja Vogel; Bruno Köhler; Christoph Springfeld; Alexander Brobeil; Peter Schirmacher; Stephan Singer; Arianeb Mehrabi Journal: Br J Cancer Date: 2022-09-06 Impact factor: 9.075
Authors: Chirayu Mohindroo; Merve Hasanov; Jane E Rogers; Wenli Dong; Laura R Prakash; Seyda Baydogan; Jonathan D Mizrahi; Michael J Overman; Gauri R Varadhachary; Robert A Wolff; Milind M Javle; David R Fogelman; Michael T Lotze; Michael P Kim; Matthew H G Katz; Shubham Pant; Ching-Wei D Tzeng; Florencia McAllister Journal: Cancer Med Date: 2021-07-11 Impact factor: 4.452