| Literature DB >> 32365197 |
Serena Zacchigna1,2, Alessia Paldino1, Inês Falcão-Pires3, Evangelos P Daskalopoulos4, Matteo Dal Ferro1, Simone Vodret2, Pierluigi Lesizza1, Antonio Cannatà1, Daniela Miranda-Silva3, André P Lourenço3, Bruno Pinamonti1, Gianfranco Sinagra1, Florian Weinberger5,6, Thomas Eschenhagen5,6, Lucie Carrier5,6, Izhak Kehat7, Carlo G Tocchetti8,9, Michele Russo8,10, Alessandra Ghigo10, James Cimino10, Emilio Hirsch10, Dana Dawson11, Michele Ciccarelli12, Marco Oliveti12, Wolfgang A Linke13, Ilona Cuijpers14,15, Stephane Heymans14,15, Nazha Hamdani16,17, Martine de Boer18, Dirk J Duncker18, Diederik Kuster19, Jolanda van der Velden19, Christophe Beauloye4,20, Luc Bertrand4, Manuel Mayr21, Mauro Giacca1,2,21, Florian Leuschner22,23, Johannes Backs22,23, Thomas Thum24,25.
Abstract
Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions. Published on behalf of the European Society of Cardiology. All rights reserved.Entities:
Keywords: Animal models; Diastolic function; Echocardiography; Standardization; Systolic function
Mesh：
Year: 2021 PMID： 32365197 DOI： 10.1093/cvr/cvaa110
Source DB: PubMed Journal: Cardiovasc Res ISSN： 0008-6363 Impact factor: 10.787