Oleg Stanislavovich Glazachev1, Maxim Andreevich Zapara1, Elena Nikolaevna Dudnik1, Vlada Germanovna Samartseva1, Davide Susta2. 1. I.M.Sechenov First Moscow State Medical University, Physiology Department, Trubetskaya str, 8, bld.2, 119992, Moscow, Russia. 2. I.M.Sechenov First Moscow State Medical University, Physiology Department, Trubetskaya str, 8, bld.2, 119992, Moscow, Russia; Dublin City University, School of Health and Human Performance, Glasnevin Campus, Dublin, Ireland. Electronic address: davide.susta@dcu.ie.
Abstract
CONTEXT: Hyperthermia is known to be beneficial to patients affected by various diseases. Brain Derived Neurotrophic Factor (BDNF) is a marker of neuroplasticity usually increased as response to acute exposure to human body stressors. Little is known about BDNF changes after repeated exposure to hyperthermia. OBJECTIVE: To investigate the effect of a repeated hyperthermia exposure programme (HTC) on serum BDNF in healthy humans. DESIGN, SETTING, PARTICIPANTS: Randomized, single-blind, controlled trial in healthy humans conducted at Sechenov University Physiology Laboratory between December 2016 and November 2018. The treatment period was 10 weeks. Researchers analysing serum BDNF and questionnaires data were blinded to participants allocation. PARTICIPANTS: Were 34 healthy male (age 20.2 ± 1.6 years). INTERVENTION: Repeated Hyperthermia exposure programme, HTC, versus Light Intermittent Exercise, LIE, programme as control (10 weeks). MAIN OUTCOME MEASURE: Change in BDNF from baseline to final visit three days after treatment completion. RESULTS:25 participants were analyzed. One participant withdrew before signing the informed consent and 8 participants (n = 3 in HTC and n = 5 in LIE) could not undertake the first assessment and were excluded. Mean change in BDNF was higher in HTC group vs LIE after both time points (after 12 and after 24 sessions). After 24 sessions BDNF was 30170 (SD 5268) pg/ml in HTC group a value that was significantly higher than 24104 (SD 2876) pg/ml measured in LIE group. BDNF concentrations were significantly higher than baseline values in HTC group only, 30170 (SD 5268) vs 26710 (SD 5437) pg/ml. CONCLUSION: A 10-week programme consisting of repeated exposure to hyperthermia resulted in a significantly higher increase of circulating BDNF compared to a programme consisting of intermittent light intensity exercise.
RCT Entities:
CONTEXT: Hyperthermia is known to be beneficial to patients affected by various diseases. Brain Derived Neurotrophic Factor (BDNF) is a marker of neuroplasticity usually increased as response to acute exposure to human body stressors. Little is known about BDNF changes after repeated exposure to hyperthermia. OBJECTIVE: To investigate the effect of a repeated hyperthermia exposure programme (HTC) on serum BDNF in healthy humans. DESIGN, SETTING, PARTICIPANTS: Randomized, single-blind, controlled trial in healthy humans conducted at Sechenov University Physiology Laboratory between December 2016 and November 2018. The treatment period was 10 weeks. Researchers analysing serum BDNF and questionnaires data were blinded to participants allocation. PARTICIPANTS: Were 34 healthy male (age 20.2 ± 1.6 years). INTERVENTION: Repeated Hyperthermia exposure programme, HTC, versus Light Intermittent Exercise, LIE, programme as control (10 weeks). MAIN OUTCOME MEASURE: Change in BDNF from baseline to final visit three days after treatment completion. RESULTS: 25 participants were analyzed. One participant withdrew before signing the informed consent and 8 participants (n = 3 in HTC and n = 5 in LIE) could not undertake the first assessment and were excluded. Mean change in BDNF was higher in HTC group vs LIE after both time points (after 12 and after 24 sessions). After 24 sessions BDNF was 30170 (SD 5268) pg/ml in HTC group a value that was significantly higher than 24104 (SD 2876) pg/ml measured in LIE group. BDNF concentrations were significantly higher than baseline values in HTC group only, 30170 (SD 5268) vs 26710 (SD 5437) pg/ml. CONCLUSION: A 10-week programme consisting of repeated exposure to hyperthermia resulted in a significantly higher increase of circulating BDNF compared to a programme consisting of intermittent light intensity exercise.
Authors: Takahiro Ogawa; Sven P Hoekstra; Yoshi-Ichiro Kamijo; Victoria L Goosey-Tolfrey; Jeremy J Walsh; Fumihiro Tajima F; Christof A Leicht Journal: PLoS One Date: 2021-12-09 Impact factor: 3.240
Authors: Steven Pratscher; Angela M Mickle; John G Marks; Harold Rocha; Felix Bartsch; Jeffrey Schmidt; Lazaro Tejera; Steven Garcia; Carlo Custodero; Federlin Jean; Cynthia Garvan; Alisa J Johnson; Ralisa Pop; Anthony Greene; Adam J Woods; Roland Staud; Roger B Fillingim; Andreas Keil; Kimberly T Sibille Journal: Nutrients Date: 2021-05-05 Impact factor: 5.717