Literature DB >> 32363669

Combined surgical excision and electron external beam radiation improves the treatment of keloids: A descriptive study.

Yinmin Wang1, Jie Ma1, Zhaofeng Zhang1, Hua Shen1.   

Abstract

Keloids are firm, fibrous nodules that form on an individual's skin and are associated with difficult symptoms as well as high recurrence rates. This study aims to improve the surgical techniques that reduce local tension after surgical excision of keloids as well as applying adjuvant radiotherapy to suppress scar formation. A total of 58 patients aged between 21 and 76 years received surgical incision of keloid and immediate postoperation low-dose radiotherapy. All patient follow-ups were performed at the out-patient department. Any sign of a keloid at the incision site was defined as treatment failure or keloid recurrence, regardless of the size. At a median follow-up of 22 months, the overall recurrence for all lesions was 8.6%, which is improved compared with previous study. In addition, all incisions performed during surgeries were healed and no signs of necrosis or the development of ulcers was observed. Our study suggests that this combined therapy provides excellent local control of keloids and shows promise for future therapy.
© 2020 Wiley Periodicals LLC.

Entities:  

Keywords:  adjuvant radiotherapy; cicatrix; keloid; surgical procedures; suture techniques

Mesh:

Year:  2020        PMID: 32363669     DOI: 10.1111/dth.13494

Source DB:  PubMed          Journal:  Dermatol Ther        ISSN: 1396-0296            Impact factor:   2.851


  3 in total

Review 1.  Adjuvant Radiotherapy for Keloids.

Authors:  Wenfang Dong; Bin Qiu; Fei Fan
Journal:  Aesthetic Plast Surg       Date:  2021-08-20       Impact factor: 2.326

Review 2.  Biomechanical Regulatory Factors and Therapeutic Targets in Keloid Fibrosis.

Authors:  Fan Feng; Mingying Liu; Lianhong Pan; Jiaqin Wu; Chunli Wang; Li Yang; Wanqian Liu; Wei Xu; Mingxing Lei
Journal:  Front Pharmacol       Date:  2022-05-09       Impact factor: 5.988

3.  Radiation-induced FAP + fibroblasts are involved in keloid recurrence after radiotherapy.

Authors:  Yan Gao; Xue Hou; Yuyin Dai; Ting Yang; Kexin Chen
Journal:  Front Cell Dev Biol       Date:  2022-08-24
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.