Literature DB >> 32363401

Application of deep learning methods in biological networks.

Shuting Jin, Xiangxiang Zeng, Feng Xia, Wei Huang, Xiangrong Liu.   

Abstract

The increase in biological data and the formation of various biomolecule interaction databases enable us to obtain diverse biological networks. These biological networks provide a wealth of raw materials for further understanding of biological systems, the discovery of complex diseases and the search for therapeutic drugs. However, the increase in data also increases the difficulty of biological networks analysis. Therefore, algorithms that can handle large, heterogeneous and complex data are needed to better analyze the data of these network structures and mine their useful information. Deep learning is a branch of machine learning that extracts more abstract features from a larger set of training data. Through the establishment of an artificial neural network with a network hierarchy structure, deep learning can extract and screen the input information layer by layer and has representation learning ability. The improved deep learning algorithm can be used to process complex and heterogeneous graph data structures and is increasingly being applied to the mining of network data information. In this paper, we first introduce the used network data deep learning models. After words, we summarize the application of deep learning on biological networks. Finally, we discuss the future development prospects of this field.
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Keywords:  biological information; biological networks; biomolecule; deep learning; deep neural network; graph neural network

Year:  2021        PMID: 32363401     DOI: 10.1093/bib/bbaa043

Source DB:  PubMed          Journal:  Brief Bioinform        ISSN: 1467-5463            Impact factor:   11.622


  27 in total

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Review 4.  Application of Multilayer Network Models in Bioinformatics.

Authors:  Yuanyuan Lv; Shan Huang; Tianjiao Zhang; Bo Gao
Journal:  Front Genet       Date:  2021-03-31       Impact factor: 4.599

5.  RNA-Associated Co-expression Network Identifies Novel Biomarkers for Digestive System Cancer.

Authors:  Zheng Chen; Zijie Shen; Zilong Zhang; Da Zhao; Lei Xu; Lijun Zhang
Journal:  Front Genet       Date:  2021-03-26       Impact factor: 4.599

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Review 9.  Recent Advances in Predicting Protein S-Nitrosylation Sites.

Authors:  Qian Zhao; Jiaqi Ma; Fang Xie; Yu Wang; Yu Zhang; Hui Li; Yuan Sun; Liqi Wang; Mian Guo; Ke Han
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Journal:  Front Genet       Date:  2022-01-03       Impact factor: 4.599

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