David Sender1, Justin Clark1, Tammy C Hoffmann2. 1. Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, 4226, Australia. 2. Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, 4226, Australia. Electronic address: thoffman@bond.edu.au.
Abstract
OBJECTIVES: Interpreting a randomized trial requires access to more than the main results paper. We aimed to determine the (1) proportion of trials referring to the protocol in the trial report and their accessibility, (2) proportion of protocols accessible from trial registry entry and by trial registration number search, and (3) types of additional publications associated with trial reports. STUDY DESIGN AND SETTING: A previously gathered sample of randomized trials of nonpharmacological interventions published in 2009 was used. Trial reports and registry entries were searched for protocol mentions and obtained when possible. Related publications were identified using citation searching. RESULTS: Of 133 trials, 96 (72%) mentioned the protocol within the report, 61 (64%) contained details about protocol acquisition, with 48 (36%) protocols obtainable. Of the 129 registered trials, 32 (25%) had protocols obtainable from registry entry. Citation tracking identified 1,030 related publications, most common were secondary analyses and qualitative studies. CONCLUSION: Trial protocols facilitate good trial conduct and interpretation. However, they are often not linked to the main report or registry and can be difficult to obtain. Many trials have related publications that are inconsistently linked. Trial registries and registration numbers could facilitate the threading of articles related to a trial, but currently do not.
OBJECTIVES: Interpreting a randomized trial requires access to more than the main results paper. We aimed to determine the (1) proportion of trials referring to the protocol in the trial report and their accessibility, (2) proportion of protocols accessible from trial registry entry and by trial registration number search, and (3) types of additional publications associated with trial reports. STUDY DESIGN AND SETTING: A previously gathered sample of randomized trials of nonpharmacological interventions published in 2009 was used. Trial reports and registry entries were searched for protocol mentions and obtained when possible. Related publications were identified using citation searching. RESULTS: Of 133 trials, 96 (72%) mentioned the protocol within the report, 61 (64%) contained details about protocol acquisition, with 48 (36%) protocols obtainable. Of the 129 registered trials, 32 (25%) had protocols obtainable from registry entry. Citation tracking identified 1,030 related publications, most common were secondary analyses and qualitative studies. CONCLUSION: Trial protocols facilitate good trial conduct and interpretation. However, they are often not linked to the main report or registry and can be difficult to obtain. Many trials have related publications that are inconsistently linked. Trial registries and registration numbers could facilitate the threading of articles related to a trial, but currently do not.
Authors: Stuart G Nicholls; Steve McDonald; Joanne E McKenzie; Kelly Carroll; Monica Taljaard Journal: J Clin Epidemiol Date: 2022-01-23 Impact factor: 7.407
Authors: Benjamin Speich; Ayodele Odutayo; Nicholas Peckham; Alexander Ooms; Jamie R Stokes; Ramon Saccilotto; Dmitry Gryaznov; Belinda von Niederhäusern; Bethan Copsey; Douglas G Altman; Matthias Briel; Sally Hopewell Journal: Trials Date: 2022-07-27 Impact factor: 2.728