| Literature DB >> 32360417 |
Marharyta V Laktsevich-Iskryk1, Anton S Rudovich1, Vladimir N Zhabinskii2, Vladimir A Khripach1, Alaksiej L Hurski1.
Abstract
A photochemical approach to 18-nor-17β-hydroxymethyl-17α-methylandrost-13-ene unit of the long-term metabolites of 17-methylated androgenic anabolic steroids (AAS) is reported. It is based on a visible light-promoted radical decarboxylative alkynylation of steroidal redox-active ester. The developed method was used in synthesis of the long-term metabolite of AAS oxymesterone.Entities:
Keywords: Androgenic anabolic steroids; Decarboxylative functionalization; Oxymesterone; Photochemical decarboxylation
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Year: 2020 PMID： 32360417 DOI： 10.1016/j.steroids.2020.108652
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668