Literature DB >> 32359411

COVID-19 and obesity-lack of clarity, guidance, and implications for care.

Stuart William Flint1, Abd A Tahrani2.   

Abstract

Entities:  

Mesh:

Year:  2020        PMID: 32359411      PMCID: PMC7190298          DOI: 10.1016/S2213-8587(20)30156-X

Source DB:  PubMed          Journal:  Lancet Diabetes Endocrinol        ISSN: 2213-8587            Impact factor:   32.069


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Coronavirus disease 2019 (COVID-19), caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was announced as a global pandemic by WHO on 11 March, 2020. Although COVID-19 is not life-threatening in most people, it can be lethal for others. The exact mortality rate varies greatly between regions and countries, particularly with an increased risk of death in people aged 70 years and older. Because of its high transmissibility, COVID-19 has challenged health-care systems worldwide, leading to pressure on intensive care beds in Italy with 9–11% of the people infected with COVID-19 requiring intensive care admission. As a result, countries took various actions to flatten the curve to allow health-care systems to cope with the demand. On 23 March, 2020, the UK Government released “Guidance for social distancing for everyone in the UK”. This guidance, among others, is much needed to reduce infection and potential spread of COVID-19. Within this guidance, several factors are identified as increasing a person's vulnerability of severe illness, and as a result, efforts to maintain social distancing is to be more stringent for these groups. One factor that has been identified as increasing a person's vulnerability of severe illness is a BMI of 40kg/m2 or higher, a cutoff that was also listed as an independent risk factor by the USA Centers for Disease Control and Prevention. Although it is recognised that a higher BMI has been associated with greater risk of type 2 diabetes, cardiovascular disease, and hypertension, all of which are predictors of poor outcomes in COVID-19, to date, no available data show adverse COVID-19 outcomes specifically in people with a BMI of 40kg/m2 or higher. This absence of data might explain why, unlike with other factors identified as reasons for a higher-risk status, there is a paucity of information to explain the reason why people with a BMI of 40kg/m2 or higher, as an independent risk factor, are included as a high-risk group. In comparison, information about the reasons that a person with diabetes is at an increased risk of severe illness have been shared widely between people living with diabetes, health-care workers, and community support networks. The scarcity of information regarding the increased risk of illness for people with a BMI higher than 40kg/m2 has led to ambiguity and might increase anxiety, given that these individuals have now been categorised as vulnerable to severe illness if they contract COVID-19. Similarly, and of concern, is that the BMI cutoff (≥40kg/m2) might give false safety for people with obesity at lower BMIs. Thus, there is a need for more evidence and information to raise awareness of why a BMI of 40kg/m2 or higher has been identified as a cutoff for increased risk of severe illness as a result of COVID-19, and also for health-care practitioners, organisations, and charities to inform and care for individuals seeking support.
  3 in total

1.  Bearing the brunt of covid-19: older people in low and middle income countries.

Authors:  Peter Lloyd-Sherlock; Shah Ebrahim; Leon Geffen; Martin McKee
Journal:  BMJ       Date:  2020-03-13

Review 2.  COVID-19 and Italy: what next?

Authors:  Andrea Remuzzi; Giuseppe Remuzzi
Journal:  Lancet       Date:  2020-03-13       Impact factor: 79.321

3.  Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.

Authors:  Fei Zhou; Ting Yu; Ronghui Du; Guohui Fan; Ying Liu; Zhibo Liu; Jie Xiang; Yeming Wang; Bin Song; Xiaoying Gu; Lulu Guan; Yuan Wei; Hui Li; Xudong Wu; Jiuyang Xu; Shengjin Tu; Yi Zhang; Hua Chen; Bin Cao
Journal:  Lancet       Date:  2020-03-11       Impact factor: 79.321

  3 in total
  17 in total

1.  Key Strategies for Clinical Management and Improvement of Healthcare Services for Cardiovascular Disease and Diabetes Patients in the Coronavirus (COVID-19) Settings: Recommendations From the REPROGRAM Consortium.

Authors:  Sonu Bhaskar; Aarushi Rastogi; Vijay Kumar Chattu; Anil Adisesh; Pravin Thomas; Negman Alvarado; Anis D Riahi; Chakrakodi N Varun; Anupama R Pai; Sarah Barsam; Antony H Walker
Journal:  Front Cardiovasc Med       Date:  2020-06-16

2.  Factors Related to Weight Gain in Subjects with Sleeve Gastrectomy During Lockdown by the COVID-19 Pandemic.

Authors:  Daniel de Luis; Olatz Izaola; David Primo; Emilia Gómez; Beatriz Torres; Juan José López Gómez; David Pacheco
Journal:  Obes Surg       Date:  2021-02-01       Impact factor: 4.129

3.  Evaluating the effect of infographics on public recall, sentiment and willingness to use face masks during the COVID-19 pandemic: a randomised internet-based questionnaire study.

Authors:  Mark Egan; Amish Acharya; Viknesh Sounderajah; Yihan Xu; Abigail Mottershaw; Rosie Phillips; Hutan Ashrafian; Ara Darzi
Journal:  BMC Public Health       Date:  2021-02-17       Impact factor: 3.295

4.  Lifestyle Acquired Immunity, Decentralized Intelligent Infrastructures, and Revised Healthcare Expenditures May Limit Pandemic Catastrophe: A Lesson From COVID-19.

Authors:  Asif Ahmed; Tasnima Haque; Mohammad Mahmudur Rahman
Journal:  Front Public Health       Date:  2020-11-05

5.  The main factors influencing COVID-19 spread and deaths in Mexico: A comparison between phases I and II.

Authors:  Francisco Benita; Francisco Gasca-Sanchez
Journal:  Appl Geogr       Date:  2021-07-27

6.  Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection.

Authors:  Donogh Maguire; Marylynne Woods; Conor Richards; Ross Dolan; Jesse Wilson Veitch; Wei M J Sim; Olivia E H Kemmett; David C Milton; Sophie L W Randall; Ly D Bui; Nicola Goldmann; Allan Cameron; Barry Laird; Dinesh Talwar; Ian Godber; Alan Davidson; Donald C McMillan
Journal:  J Transl Med       Date:  2020-09-15       Impact factor: 5.531

Review 7.  Hypercoagulopathy and Adipose Tissue Exacerbated Inflammation May Explain Higher Mortality in COVID-19 Patients With Obesity.

Authors:  Gabriel Pasquarelli-do-Nascimento; Heloísa Antoniella Braz-de-Melo; Sara Socorro Faria; Igor de Oliveira Santos; Gary P Kobinger; Kelly Grace Magalhães
Journal:  Front Endocrinol (Lausanne)       Date:  2020-07-28       Impact factor: 5.555

8.  Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19.

Authors:  Jang Hyun Park; Heung Kyu Lee
Journal:  Front Immunol       Date:  2020-08-28       Impact factor: 7.561

9.  Leading Factors for Weight Gain during COVID-19 Lockdown in a Spanish Population: A Cross-Sectional Study.

Authors:  Enric Sánchez; Albert Lecube; Diego Bellido; Susana Monereo; María M Malagón; Francisco J Tinahones
Journal:  Nutrients       Date:  2021-03-10       Impact factor: 5.717

10.  Obesity and the Risk of Intubation or Death in Patients With Coronavirus Disease 2019.

Authors:  Rachel C Frank; Sean R Mendez; Elizabeth K Stevenson; James S Guseh; Mabel Chung; Michael G Silverman
Journal:  Crit Care Med       Date:  2020-11       Impact factor: 9.296

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