Stephan K W Schwarz1,2, Christopher Prabhakar3,4. 1. Department of Anesthesiology, Pharmacology & Therapeutics, The University of British Columbia, Medical Sciences Block C, 2176 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. stephan.schwarz@ubc.ca. 2. Department of Anesthesia, St. Paul's Hospital/Providence Health Care, Providence Level 3, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada. stephan.schwarz@ubc.ca. 3. Department of Anesthesiology, Pharmacology & Therapeutics, The University of British Columbia, Medical Sciences Block C, 2176 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. 4. Department of Anesthesia, St. Paul's Hospital/Providence Health Care, Providence Level 3, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.