Michael Rullmann1, Anke McLeod2, Michel J Grothe3, Osama Sabri2, Henryk Barthel. 1. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; and rullmann@medizin.uni-leipzig.de. 2. Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany; and. 3. German Center for Neurodegenerative Diseases-Rostock/Greifswald, Rostock, Germany.
Abstract
It was hypothesized that the brain β-amyloid buildup curve plateaus at an early symptomatic stage of Alzheimer disease (AD). Atrophy-related partial-volume effects (PVEs) degrade signal in hot-spot imaging techniques such as amyloid PET. The current study, a longitudinal analysis of amyloid-sensitive PET data, investigated the effect on the shape of the β-amyloid curve in AD when PVE correction (PVEC) is applied. Methods: We analyzed baseline and 2-y follow-up data for 216 symptomatic individuals on the AD continuum (positive amyloid status) enrolled in the Alzheimer's Disease Neuroimaging Initiative (17 with AD dementia and 199 with mild cognitive impairment), including 18F-florbetapir PET, MRI, and Mini Mental State Examination scores. For PVEC, the modified Müller-Gärtner method was performed. Results: Compared with non-PVE-corrected data, PVE-corrected data yielded significantly higher changes in regional and composite SUV ratio (SUVR) over time (P = 0.0002 for composite SUVRs). Longitudinal SUVR changes in relation to Mini Mental State Examination decreases showed a significantly higher slope for the regression line in the PVE-corrected than in the non-PVE-corrected PET data (F 1 = 7.1, P = 0.008). Conclusion: These PVEC results indicate that the β-amyloid buildup curve does not plateau at an early symptomatic disease stage. A further evaluation of the impact of PVEC on the in vivo characterization of time-dependent AD pathology, including the reliable assessment and comparison of other amyloid tracers, is warranted.
It was hypothesized that the brain β-amyloid buildup curve plateaus at an early symptomatic stage of Alzheimer disease (AD). Atrophy-related partial-volume effects (PVEs) degrade signal in hot-spot imaging techniques such as amyloid PET. The current study, a longitudinal analysis of amyloid-sensitive PET data, investigated the effect on the shape of the β-amyloid curve in AD when PVE correction (PVEC) is applied. Methods: We analyzed baseline and 2-y follow-up data for 216 symptomatic individuals on the AD continuum (positive amyloid status) enrolled in the Alzheimer's Disease Neuroimaging Initiative (17 with AD dementia and 199 with mild cognitive impairment), including 18F-florbetapir PET, MRI, and Mini Mental State Examination scores. For PVEC, the modified Müller-Gärtner method was performed. Results: Compared with non-PVE-corrected data, PVE-corrected data yielded significantly higher changes in regional and composite SUV ratio (SUVR) over time (P = 0.0002 for composite SUVRs). Longitudinal SUVR changes in relation to Mini Mental State Examination decreases showed a significantly higher slope for the regression line in the PVE-corrected than in the non-PVE-corrected PET data (F 1 = 7.1, P = 0.008). Conclusion: These PVEC results indicate that the β-amyloid buildup curve does not plateau at an early symptomatic disease stage. A further evaluation of the impact of PVEC on the in vivo characterization of time-dependent AD pathology, including the reliable assessment and comparison of other amyloid tracers, is warranted.
Authors: Meryl A Butters; William E Klunk; Chester A Mathis; Julie C Price; Scott K Ziolko; Jessica A Hoge; Nicholas D Tsopelas; Brian J Lopresti; Charles F Reynolds; Steven T DeKosky; Carolyn C Meltzer Journal: Alzheimer Dis Assoc Disord Date: 2008 Jul-Sep Impact factor: 2.703
Authors: Victor L Villemagne; Samantha Burnham; Pierrick Bourgeat; Belinda Brown; Kathryn A Ellis; Olivier Salvado; Cassandra Szoeke; S Lance Macaulay; Ralph Martins; Paul Maruff; David Ames; Christopher C Rowe; Colin L Masters Journal: Lancet Neurol Date: 2013-03-08 Impact factor: 44.182
Authors: Andrew J Aschenbrenner; Brian A Gordon; Tammie L S Benzinger; John C Morris; Jason J Hassenstab Journal: Neurology Date: 2018-08-01 Impact factor: 9.910
Authors: P M Doraiswamy; R A Sperling; K Johnson; E M Reiman; T Z Wong; M N Sabbagh; C H Sadowsky; A S Fleisher; A Carpenter; A D Joshi; M Lu; M Grundman; M A Mintun; D M Skovronsky; M J Pontecorvo Journal: Mol Psychiatry Date: 2014-03-11 Impact factor: 15.992
Authors: Yi Su; Shaney Flores; Guoqiao Wang; Russ C Hornbeck; Benjamin Speidel; Nelly Joseph-Mathurin; Andrei G Vlassenko; Brian A Gordon; Robert A Koeppe; William E Klunk; Clifford R Jack; Martin R Farlow; Stephen Salloway; Barbara J Snider; Sarah B Berman; Erik D Roberson; Jared Brosch; Ivonne Jimenez-Velazques; Christopher H van Dyck; Douglas Galasko; Shauna H Yuan; Suman Jayadev; Lawrence S Honig; Serge Gauthier; Ging-Yuek R Hsiung; Mario Masellis; William S Brooks; Michael Fulham; Roger Clarnette; Colin L Masters; David Wallon; Didier Hannequin; Bruno Dubois; Jeremie Pariente; Raquel Sanchez-Valle; Catherine Mummery; John M Ringman; Michel Bottlaender; Gregory Klein; Smiljana Milosavljevic-Ristic; Eric McDade; Chengjie Xiong; John C Morris; Randall J Bateman; Tammie L S Benzinger Journal: Alzheimers Dement (Amst) Date: 2019-02-22
Authors: Christopher G Schwarz; David T Jones; Jeffrey L Gunter; Val J Lowe; Prashanthi Vemuri; Matthew L Senjem; Ronald C Petersen; David S Knopman; Clifford R Jack Journal: Hum Brain Mapp Date: 2017-04-22 Impact factor: 5.038
Authors: Jiarui Yang; Chenhui Hu; Ning Guo; Joyita Dutta; Lucia M Vaina; Keith A Johnson; Jorge Sepulcre; Georges El Fakhri; Quanzheng Li Journal: Sci Rep Date: 2017-10-12 Impact factor: 4.379
Authors: Sebastian Schuster; Leonie Beyer; Carla Palleis; Stefanie Harris; Julia Schmitt; Endy Weidinger; Catharina Prix; Kai Bötzel; Adrian Danek; Boris-Stephan Rauchmann; Sophia Stöcklein; Simon Lindner; Marcus Unterrainer; Nathalie L Albert; Lena M Mittlmeier; Christian Wetzel; Rainer Rupprecht; Axel Rominger; Peter Bartenstein; Robert Perneczky; Johannes Levin; Günter U Höglinger; Matthias Brendel; Franziska J Dekorsy Journal: Brain Sci Date: 2022-01-31
Authors: Adam Martersteck; Ivan Ayala; Daniel T Ohm; Callen Spencer; Christina Coventry; Sandra Weintraub; Eileen H Bigio; M -Marsel Mesulam; Changiz Geula; Emily Rogalski Journal: Acta Neuropathol Commun Date: 2022-08-09 Impact factor: 7.578