Literature DB >> 3235548

High-performance liquid chromatographic analysis of desferrioxamine. Pharmacokinetic and metabolic studies.

T P Kruck1, K Teichert-Kuliszewska, E Fisher, W Kalow, D R McLachlan.   

Abstract

A high-performance liquid chromatographic method has been developed that permits determination and quantitation of desferrioxamine and metabolites as their iron (III) complexes in small samples of mammalian plasma at levels encountered with ion-specific chelation treatments. The technique permits measurement of desferrioxamine and metabolite concentrations which can be used in pharmacokinetic studies. A human study is presented as an example.

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Year:  1988        PMID: 3235548     DOI: 10.1016/s0378-4347(00)80599-x

Source DB:  PubMed          Journal:  J Chromatogr


  1 in total

1.  Clinically achievable plasma deferoxamine concentrations are therapeutic in a rat model of Pneumocystis carinii pneumonia.

Authors:  S Merali; K Chin; L Del Angel; R W Grady; M Armstrong; A B Clarkson
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

  1 in total

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