BACKGROUND: In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy. PATIENTS AND METHODS: This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for colposcopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected. RESULTS: A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated. CONCLUSION: HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity. Copyright
BACKGROUND: In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy. PATIENTS AND METHODS: This is an observational prospective cohort study performed in 7 academic Obstetrics and Gynaecology Departments across Greece between 2009-2019. Cases were women that had completed HPV vaccination before coitarche and were referred for colposcopy due to abnormal cytology. For each vaccinated woman an unvaccinated matched control was selected. RESULTS: A total of 849 women who had been vaccinated before coitarche and 849 unvaccinated controls were recruited. The combination of cytological, colposcopic and molecular findings necessitated treatment in only a single case among vaccinated (0.1%) and in 8.4% among unvaccinated. CONCLUSION: HPV vaccination at a proper age can markedly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity. Copyright
Authors: A Szarewski; W A J Poppe; S R Skinner; C M Wheeler; J Paavonen; P Naud; J Salmeron; S-N Chow; D Apter; H Kitchener; X Castellsagué; J C Teixeira; J Hedrick; U Jaisamrarn; G Limson; S Garland; B Romanowski; F Y Aoki; T F Schwarz; F X Bosch; D M Harper; K Hardt; T Zahaf; D Descamps; F Struyf; M Lehtinen; G Dubin Journal: Int J Cancer Date: 2011-10-23 Impact factor: 7.396
Authors: Michaela T Hall; Kate T Simms; Jie-Bin Lew; Megan A Smith; Julia Ml Brotherton; Marion Saville; Ian H Frazer; Karen Canfell Journal: Lancet Public Health Date: 2018-10-02
Authors: Maria Kyrgiou; Anita Mitra; Marc Arbyn; Sofia Melina Stasinou; Pierre Martin-Hirsch; Phillip Bennett; Evangelos Paraskevaidis Journal: BMJ Date: 2014-10-28
Authors: I Kalliala; A Athanasiou; A A Veroniki; G Salanti; O Efthimiou; N Raftis; S Bowden; M Paraskevaidi; K Aro; M Arbyn; P Bennett; P Nieminen; E Paraskevaidis; M Kyrgiou Journal: Ann Oncol Date: 2020-01-03 Impact factor: 32.976