Song Iy Han1, Sung-Chul Lim2. 1. Division of Premedical Science College of Medicine, Chosun University, Gwangju, Republic of Korea. 2. Department of Pathology, College of Medicine, Chosun University, Gwangju, Republic of Korea sclim@chosun.ac.kr.
Abstract
BACKGROUND/AIM: Cyclin-dependent kinase 8 (CDK8) is known to play an important role in the early development and progression of various cancers, and the Wnt/β-catenin pathway is also involved in cancer progression. Nevertheless, relatively little is known about the regulatory mechanisms of the β-catenin pathway in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: The complete clinicopathological features of 122 pairs of HCC and adjacent non-tumor tissues were analyzed and immunohistochemistry was used to detect the aberrant expression of CDK8 and β-catenin. Overall survival rates (OSRs) were evaluated using the Kaplan-Meier method and Cox multivariate analysis was used to assess the prognostic values. RESULTS: Aberrant expression of nuclear β-catenin and CDK8 are independent prognostic variables that negatively affect the OSR. The aberrant expression of CDK8 was associated with the dysregulated expression of β-catenin and correlated with a poor prognosis. CONCLUSION: Inhibition of CDK8 and/or nuclear β-catenin expression pattern could serve as a promising therapeutic strategy for the treatment of HCC. Copyright
BACKGROUND/AIM: Cyclin-dependent kinase 8 (CDK8) is known to play an important role in the early development and progression of various cancers, and the Wnt/β-catenin pathway is also involved in cancer progression. Nevertheless, relatively little is known about the regulatory mechanisms of the β-catenin pathway in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: The complete clinicopathological features of 122 pairs of HCC and adjacent non-tumor tissues were analyzed and immunohistochemistry was used to detect the aberrant expression of CDK8 and β-catenin. Overall survival rates (OSRs) were evaluated using the Kaplan-Meier method and Cox multivariate analysis was used to assess the prognostic values. RESULTS: Aberrant expression of nuclear β-catenin and CDK8 are independent prognostic variables that negatively affect the OSR. The aberrant expression of CDK8 was associated with the dysregulated expression of β-catenin and correlated with a poor prognosis. CONCLUSION: Inhibition of CDK8 and/or nuclear β-catenin expression pattern could serve as a promising therapeutic strategy for the treatment of HCC. Copyright
Authors: Martina S J McDermott; Alexander A Chumanevich; Chang-Uk Lim; Jiaxin Liang; Mengqian Chen; Serena Altilia; David Oliver; James M Rae; Michael Shtutman; Hippokratis Kiaris; Balázs Győrffy; Igor B Roninson; Eugenia V Broude Journal: Oncotarget Date: 2017-02-21