Literature DB >> 32353353

The debate continues - What is the role of MCU and mitochondrial calcium uptake in the heart?

Joanne F Garbincius1, Timothy S Luongo2, John W Elrod3.   

Abstract

Since the identification of the mitochondrial calcium uniporter (MCU) in 2011, several studies utilizing genetic models have attempted to decipher the role of mitochondrial calcium uptake in cardiac physiology. Confounding results in various mutant mouse models have led to an ongoing debate regarding the function of MCU in the heart. In this review, we evaluate and discuss the totality of evidence for mitochondrial calcium uptake in the cardiac stress response and highlight recent reports that implicate MCU in the control of homeostatic cardiac metabolism and function. This review concludes with a discussion of current gaps in knowledge and remaining experiments to define how MCU contributes to contractile function, cell death, metabolic regulation, and heart failure progression.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Calcium; Cardiac function; Energetics; Ischemia reperfusion; MCU; MICU1; Mitochondria; NCLX; Permeability transition

Mesh：

Substances：

Year:  2020        PMID： 32353353      PMCID： PMC7938348          DOI： 10.1016/j.yjmcc.2020.04.029

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


  112 in total

1.  Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation.

Authors:  F D VASINGTON; J V MURPHY
Journal:  J Biol Chem       Date:  1962-08       Impact factor: 5.157

2.  Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

Authors:  Tyler P Rasmussen; Yuejin Wu; Mei-ling A Joiner; Olha M Koval; Nicholas R Wilson; Elizabeth D Luczak; Qinchuan Wang; Biyi Chen; Zhan Gao; Zhiyong Zhu; Brett A Wagner; Jamie Soto; Michael L McCormick; William Kutschke; Robert M Weiss; Liping Yu; Ryan L Boudreau; E Dale Abel; Fenghuang Zhan; Douglas R Spitz; Garry R Buettner; Long-Sheng Song; Leonid V Zingman; Mark E Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-07       Impact factor: 11.205

3.  MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.

Authors:  Erol C Bayraktar; Lou Baudrier; Ceren Özerdem; Caroline A Lewis; Sze Ham Chan; Tenzin Kunchok; Monther Abu-Remaileh; Andrew L Cangelosi; David M Sabatini; Kıvanç Birsoy; Walter W Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2018-12-12       Impact factor: 11.205

4.  MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.

Authors:  Jonathan P Lambert; Timothy S Luongo; Dhanendra Tomar; Pooja Jadiya; Erhe Gao; Xueqian Zhang; Anna Maria Lucchese; Devin W Kolmetzky; Neil S Shah; John W Elrod
Journal:  Circulation       Date:  2019-09-19       Impact factor: 29.690

5.  The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms.

Authors:  D G Nicholls; I D Scott
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

Review 6.  Glucose metabolism and cardiac hypertrophy.

Authors:  Stephen C Kolwicz; Rong Tian
Journal:  Cardiovasc Res       Date:  2011-05-01       Impact factor: 10.787

7.  The mitochondrial calcium uniporter is a highly selective ion channel.

Authors:  Yuriy Kirichok; Grigory Krapivinsky; David E Clapham
Journal:  Nature       Date:  2004-01-22       Impact factor: 49.962

8.  Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

Authors:  Clare V Logan; György Szabadkai; Jenny A Sharpe; David A Parry; Silvia Torelli; Anne-Marie Childs; Marjolein Kriek; Rahul Phadke; Colin A Johnson; Nicola Y Roberts; David T Bonthron; Karen A Pysden; Tamieka Whyte; Iulia Munteanu; A Reghan Foley; Gabrielle Wheway; Katarzyna Szymanska; Subaashini Natarajan; Zakia A Abdelhamed; Joanne E Morgan; Helen Roper; Gijs W E Santen; Erik H Niks; W Ludo van der Pol; Dick Lindhout; Anna Raffaello; Diego De Stefani; Johan T den Dunnen; Yu Sun; Ieke Ginjaar; Caroline A Sewry; Matthew Hurles; Rosario Rizzuto; Michael R Duchen; Francesco Muntoni; Eamonn Sheridan
Journal:  Nat Genet       Date:  2013-12-15       Impact factor: 38.330

9.  Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.

Authors:  Alexander G Bick; Hiroko Wakimoto; Kimberli J Kamer; Yasemin Sancak; Olga Goldberger; Anna Axelsson; Daniel M DeLaughter; Joshua M Gorham; Vamsi K Mootha; J G Seidman; Christine E Seidman
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-09       Impact factor: 11.205

10.  Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.

Authors:  Alyssa A Lombardi; Andrew A Gibb; Ehtesham Arif; Devin W Kolmetzky; Dhanendra Tomar; Timothy S Luongo; Pooja Jadiya; Emma K Murray; Pawel K Lorkiewicz; György Hajnóczky; Elizabeth Murphy; Zoltan P Arany; Daniel P Kelly; Kenneth B Margulies; Bradford G Hill; John W Elrod
Journal:  Nat Commun       Date:  2019-10-04       Impact factor: 14.919
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  10 in total

1.  MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca2+ release in hypertrophic rat cardiomyocytes.

Authors:  Shanna Hamilton; Radmila Terentyeva; Fruzsina Perger; Benjamín Hernández Orengo; Benjamin Martin; Matthew W Gorr; Andriy E Belevych; Richard T Clements; Sandor Györke; Dmitry Terentyev
Journal:  Am J Physiol Heart Circ Physiol       Date:  2021-08-20       Impact factor: 5.125

2.  Enhanced NCLX-dependent mitochondrial Ca2+ efflux attenuates pathological remodeling in heart failure.

Authors:  Joanne F Garbincius; Timothy S Luongo; Pooja Jadiya; Alycia N Hildebrand; Devin W Kolmetzky; Adam S Mangold; Rajika Roy; Jessica Ibetti; Mary Nwokedi; Walter J Koch; John W Elrod
Journal:  J Mol Cell Cardiol       Date:  2022-03-28       Impact factor: 5.763

3.  Is the Failing Heart Starved of Mitochondrial Calcium?

Authors:  Joanne F Garbincius; John W Elrod
Journal:  Circ Res       Date:  2021-04-15       Impact factor: 17.367

4.  Mitochondria in Pathological Cardiac Remodeling.

Authors:  Michael P Lazaropoulos; John W Elrod
Journal:  Curr Opin Physiol       Date:  2022-02-19

Review 5.  Mitochondrial calcium exchange in physiology and disease.

Authors:  Joanne F Garbincius; John W Elrod
Journal:  Physiol Rev       Date:  2021-10-26       Impact factor: 37.312

Review 6.  Cellular and mitochondrial mechanisms of atrial fibrillation.

Authors:  Fleur E Mason; Julius Ryan D Pronto; Khaled Alhussini; Christoph Maack; Niels Voigt
Journal:  Basic Res Cardiol       Date:  2020-11-30       Impact factor: 17.165

Review 7.  Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies.

Authors:  Cosimo Andrea Stamerra; Paolo Di Giosia; Paolo Giorgini; Claudio Ferri; Vasily N Sukhorukov; Amirhossein Sahebkar
Journal:  Oxid Med Cell Longev       Date:  2022-08-02       Impact factor: 7.310

Review 8.  Calcium influx through the mitochondrial calcium uniporter holocomplex, MCUcx.

Authors:  Liron Boyman; Maura Greiser; W Jonathan Lederer
Journal:  J Mol Cell Cardiol       Date:  2020-11-02       Impact factor: 5.763

Review 9.  Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications.

Authors:  Hai-Xia Xu; Su-Mei Cui; Ying-Mei Zhang; Jun Ren
Journal:  Acta Pharmacol Sin       Date:  2020-07-21       Impact factor: 6.150

10.  MICU1-dependent mitochondrial calcium uptake regulates lung alveolar type 2 cell plasticity and lung regeneration.

Authors:  Mir Ali; Xiaoying Zhang; Ryan LaCanna; Dhanendra Tomar; John W Elrod; Ying Tian
Journal:  JCI Insight       Date:  2022-02-22
  10 in total

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