Literature DB >> 32353091

Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity.

Marcos R Scheide1, Alex R Schneider1, Guilherme A M Jardim1, Guilherme M Martins1, Daniele C Durigon1, Sumbal Saba2, Jamal Rafique3, Antonio L Braga1.   

Abstract

Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives. This reaction proceeds with 0.2 equiv. of nBu4NClO4 as an electrolyte and Pt working electrodes in an undivided cell, resulting in the selenyl-dihydrofurans in good to excellent yields. Furthermore, several of the synthesized products presented a high percentage of acetylcholinesterase (AChE) inhibition, highlighting their potential anti-Alzheimer activity.

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Year:  2020        PMID： 32353091     DOI： 10.1039/d0ob00629g

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Versatile Electrochemical Synthesis of Selenylbenzo[b]Furan Derivatives Through the Cyclization of 2-Alkynylphenols.

Authors:  Carlos V Doerner; Marcos R Scheide; Celso R Nicoleti; Daniele C Durigon; Vinícius D Idiarte; Martinho J A Sousa; Samuel R Mendes; Sumbal Saba; José S S Neto; Guilherme M Martins; Jamal Rafique; Antonio L Braga
Journal:  Front Chem       Date:  2022-05-17       Impact factor: 5.545

2.  Borophosphate glass as an active media for CuO nanoparticle growth: an efficient catalyst for selenylation of oxadiazoles and application in redox reactions.

Authors:  Marcos M Peterle; Sumbal Saba; José S S Neto; Guilherme F Lenz; Rosane Dias Cezar; Marcos R Scheide; Jorlandio F Felix; Giancarlo V Botteselle; Ricardo Schneider; Jamal Rafique; Antonio L Braga
Journal:  Sci Rep       Date:  2020-09-17       Impact factor: 4.379

3.  Synthesis of 2,1,3-Benzoxadiazole Derivatives as New Fluorophores-Combined Experimental, Optical, Electro, and Theoretical Study.

Authors:  Tiago E A Frizon; André A Vieira; Fabricia N da Silva; Sumbal Saba; Giliandro Farias; Bernardo de Souza; Eduardo Zapp; Michell N Lôpo; Hugo de C Braga; Felipe Grillo; Sergio F Curcio; Thiago Cazati; Jamal Rafique
Journal:  Front Chem       Date:  2020-05-12       Impact factor: 5.221

4.  Selenylated-oxadiazoles as promising DNA intercalators: Synthesis, electronic structure, DNA interaction and cleavage.

Authors:  Jamal Rafique; Giliandro Farias; Sumbal Saba; Eduardo Zapp; Ismael Casagrande Bellettini; Cristian Andrey Momoli Salla; Ivan Helmuth Bechtold; Marcos Roberto Scheide; José Sebastião Santos Neto; David Monteiro de Souza Junior; Hugo de Campos Braga; Luiz Fernando Belchior Ribeiro; Francine Gastaldon; Claus Tröger Pich; Tiago Elias Allievi Frizon
Journal:  Dyes Pigm       Date:  2020-05-07       Impact factor: 4.889

Review 5.  "Green Is the Color": An Update on Ecofriendly Aspects of Organoselenium Chemistry.

Authors:  Juliano B Azeredo; Filipe Penteado; Vanessa Nascimento; Luca Sancineto; Antonio L Braga; Eder João Lenardao; Claudio Santi
Journal:  Molecules       Date:  2022-02-28       Impact factor: 4.411

6.  Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress.

Authors:  Tiago E A Frizon; José H Cararo; Sumbal Saba; Gustavo C Dal-Pont; Monique Michels; Hugo C Braga; Tairine Pimentel; Felipe Dal-Pizzol; Samira S Valvassori; Jamal Rafique
Journal:  Oxid Med Cell Longev       Date:  2020-05-28       Impact factor: 6.543
  6 in total

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