Literature DB >> 32350493

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria.

Hadyn L Parker1, Ruben M F Tomás, Christopher M Furze, Collette S Guy, Elizabeth Fullam.   

Abstract

The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

Entities:  

Year:  2020        PMID： 32350493     DOI： 10.1039/d0ob00253d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  5 in total

Review 1.  Chemical Reporters for Bacterial Glycans: Development and Applications.

Authors:  Nicholas Banahene; Herbert W Kavunja; Benjamin M Swarts
Journal:  Chem Rev       Date:  2021-12-14       Impact factor: 60.622

2.  The role of chemoenzymatic synthesis in advancing trehalose analogues as tools for combatting bacterial pathogens.

Authors:  Karishma Kalera; Alicyn I Stothard; Peter J Woodruff; Benjamin M Swarts
Journal:  Chem Commun (Camb)       Date:  2020-10-01       Impact factor: 6.222

3.  PPE51 mediates uptake of trehalose across the mycomembrane of Mycobacterium tuberculosis.

Authors:  Mohammed Rizwan Babu Sait; Hendrik Koliwer-Brandl; Jessica A Stewart; Benjamin M Swarts; Marc Jacobsen; Thomas R Ioerger; Rainer Kalscheuer
Journal:  Sci Rep       Date:  2022-02-08       Impact factor: 4.379

4.  AuCl3-Catalyzed Hemiacetal Activation for the Stereoselective Synthesis of 2-Deoxy Trehalose Derivatives.

Authors:  Robin Jeanneret; Carlo Walz; Maarten van Meerbeek; Sarah Coppock; M Carmen Galan
Journal:  Org Lett       Date:  2022-08-22       Impact factor: 6.072

5.  Biochemical and phenotypic characterisation of the Mycobacterium smegmatis transporter UspABC.

Authors:  Magdalena Karlikowska; Albel Singh; Apoorva Bhatt; Sascha Ott; Andrew R Bottrill; Gurdyal S Besra; Elizabeth Fullam
Journal:  Cell Surf       Date:  2021-04-24
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.