Jin Li1,2, Yang Liu1, Hua Zhang3, Hong Hua1. 1. Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China. 2. School of Stomatology, Guangdong Province, Jinan University, Guangzhou, P. R. China. 3. Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, P. R. China.
Abstract
OBJECTIVES: This study aimed to examine the association between hyperglycemia and the malignant transformation of oral leukoplakia (OLK). PATIENTS AND METHODS: This retrospective case-control study involved 133 patients with the malignant transformation of OLK into oral squamous cell carcinoma (case group) and 266 patients with untransformed OLK (control group). The clinical history and follow-up data included age, gender, lesion size and location, and fasting plasma glucose. Logistic regression analysis, Kaplan-Meier survival analysis, and univariate and multivariate Cox regression analyses were used to assess the effects of risk factors on the malignant transformation of OLK. RESULTS: Hyperglycemia (adjusted hazard ratio [AHR] = 4.7, p = .001), non-homogenous OLK (AHR = 3.0, p < .001), location of the lesion on the ventral surface of the tongue or floor of the mouth (AHR = 3.6, p < .001), and epithelial dysplasia (AHR = 2.8, p = .005) had significant effects on the malignant transformation of OLK. CONCLUSION: Hyperglycemia, non-homogenous OLK, location of the lesion on the ventral surface of the tongue or floor of the mouth, and epithelial dysplasia might be associated with malignant transformation of OLK.
OBJECTIVES: This study aimed to examine the association between hyperglycemia and the malignant transformation of oral leukoplakia (OLK). PATIENTS AND METHODS: This retrospective case-control study involved 133 patients with the malignant transformation of OLK into oral squamous cell carcinoma (case group) and 266 patients with untransformed OLK (control group). The clinical history and follow-up data included age, gender, lesion size and location, and fasting plasma glucose. Logistic regression analysis, Kaplan-Meier survival analysis, and univariate and multivariate Cox regression analyses were used to assess the effects of risk factors on the malignant transformation of OLK. RESULTS:Hyperglycemia (adjusted hazard ratio [AHR] = 4.7, p = .001), non-homogenous OLK (AHR = 3.0, p < .001), location of the lesion on the ventral surface of the tongue or floor of the mouth (AHR = 3.6, p < .001), and epithelial dysplasia (AHR = 2.8, p = .005) had significant effects on the malignant transformation of OLK. CONCLUSION:Hyperglycemia, non-homogenous OLK, location of the lesion on the ventral surface of the tongue or floor of the mouth, and epithelial dysplasia might be associated with malignant transformation of OLK.
Authors: Jose Bagan; Miguel Martorell; Jose L Cebrián; Andrea Rubert; Leticia Bagán; Carlos Mezquida; David Hervás Journal: Clin Oral Investig Date: 2022-04-26 Impact factor: 3.606