Hang T T Tran1,2,3, Ha T T Le1, Hanh T P Tran1, Dung T K Khu1,4, Hugo Lagercrantz5, Dien M Tran2, Birger Winbladh5, Lena Hellström-Westas6, Tobias Alfvén3,7, Linus Olson1,4,5,6,8. 1. Neonatal Intensive Care Unit, Vietnam National Children's Hospital (VNCH), Hanoi, Vietnam. 2. Research Institute for Child Health, Hanoi, Vietnam. 3. Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. 4. Training and Research Academic Collaboration, Vietnam-Sweden. 5. Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. 6. Department of Womens and Children's Health, Uppsala University, Uppsala, Sweden. 7. Sachs' Children and Youth Hospital, Stockholm, Sweden. 8. Department of Clinical Research and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Abstract
AIM: To evaluate whether phase-changing material can be used for therapeutic hypothermia of asphyxiated newborns in low-resource settings. METHODS: Prospective interventional study of asphyxiated term infants fulfilling criteria for hypothermia treatment at Vietnam National Children's Hospital from September 2014 to September 2016. Hypothermia was induced within 6 hours after birth and maintained for 72 hours by a phase-changing material mattress with melting point of 32°C. Rectal temperature was continuously measured, and deviations from target temperature range 33.5-34.5°C were recorded. RESULTS: In total 52 infants (mean gestational age 39.3 ± 1.1 weeks) included and cooled, the median temperature at initiation of cooling was 35.3 (IQR 34.5-35.9)°C. The median time to reach target temperature was 2.5 (IQR 2-3) hours. The mean temperature during the cooling phase was 33.95 ± 0.2°C. Throughout the cooling phase, the target temperature range (33.5-34.5°C) was maintained more than 80% of the time. Rate of rewarming was 0.5 ± 0.14°C/hour. CONCLUSION: Phase-changing material can be used as an effective cooling method. Though not a servo-controlled system, it is easy to induce hypothermia, maintain target temperature and rewarm infants in a slow and controlled manner without need for frequent changes and minimum risk of skin injury.
AIM: To evaluate whether phase-changing material can be used for therapeutic hypothermia of asphyxiated newborns in low-resource settings. METHODS: Prospective interventional study of asphyxiated term infants fulfilling criteria for hypothermia treatment at Vietnam National Children's Hospital from September 2014 to September 2016. Hypothermia was induced within 6 hours after birth and maintained for 72 hours by a phase-changing material mattress with melting point of 32°C. Rectal temperature was continuously measured, and deviations from target temperature range 33.5-34.5°C were recorded. RESULTS: In total 52 infants (mean gestational age 39.3 ± 1.1 weeks) included and cooled, the median temperature at initiation of cooling was 35.3 (IQR 34.5-35.9)°C. The median time to reach target temperature was 2.5 (IQR 2-3) hours. The mean temperature during the cooling phase was 33.95 ± 0.2°C. Throughout the cooling phase, the target temperature range (33.5-34.5°C) was maintained more than 80% of the time. Rate of rewarming was 0.5 ± 0.14°C/hour. CONCLUSION: Phase-changing material can be used as an effective cooling method. Though not a servo-controlled system, it is easy to induce hypothermia, maintain target temperature and rewarm infants in a slow and controlled manner without need for frequent changes and minimum risk of skin injury.
Authors: Tina Dempsey; Huong Lien Nguyen; Huong Thu Nguyen; Xuan Anh Bui; Phuong Thi Thu Pham; Toan K Nguyen; Francesco Cavallin; Daniele Trevisanuto; Susanna Myrnerts Höök; Nicolas Pejovic; Mats Blennow; Linus Olson; Hien Vu; Anh Duy Nguyen; Tobias Alfvén Journal: Children (Basel) Date: 2022-02-28