Literature DB >> 323459

Effect of active drug metabolites on plasma level-response correlations.

A J Atkinson, J M Strong.   

Abstract

Mesh：

Substances：

Year:  1977        PMID： 323459     DOI： 10.1007/bf01066214

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


× No keyword cloud information.
  30 in total

1.  Absolute bioavailability in man of N-acetylprocainamide determined by a novel stable isotope method.

Authors:  J M Strong; J S Dutcher; W K Lee; A J Atkinson
Journal:  Clin Pharmacol Ther       Date:  1975-11       Impact factor: 6.875

2.  New drugs in the treatment of petit mal epilepsy.

Authors:  F T ZIMMERMAN
Journal:  Am J Psychiatry       Date:  1953-04       Impact factor: 18.112

3.  The convulsant potency of lidocaine and its N-dealkylated metabolites.

Authors:  J Blumer; J M Strong; A J Atkinson
Journal:  J Pharmacol Exp Ther       Date:  1973-07       Impact factor: 4.030

4.  Methsuximide overdose. Delayed onset of profound coma.

Authors:  S B Karch
Journal:  JAMA       Date:  1973-03-26       Impact factor: 56.272

5.  Procainamide dosage schedules, plasma concentrations, and clinical effects.

Authors:  J Koch-Weser; S W Klein
Journal:  JAMA       Date:  1971-03-01       Impact factor: 56.272

6.  Identification and activity of the hydroxy metabolite that accumulates in the plasma of humans intoxicated with glutethimide.

Authors:  J J Ambre; L J Fischer
Journal:  Drug Metab Dispos       Date:  1974 Mar-Apr       Impact factor: 3.922

7.  Hemodialysis for severe procainamide toxicity: clinical and pharmacokinetic observations.

Authors:  A J Atkinson; F A Krumlovsky; C M Huang; F del Greco
Journal:  Clin Pharmacol Ther       Date:  1976-11       Impact factor: 6.875

8.  Mechanism of convulsions elicited by local anesthetic agents. I. Local anesthetic depression of electrically-induced seizures in man.

Authors:  J A Wikinski; J E Usubiaga; R L Morales; A Torrieri; L E Usubiaga
Journal:  Anesth Analg       Date:  1970 May-Jun       Impact factor: 5.108

9.  The effects of human contact on cardiac arrhythmia in coronary care patients.

Authors:  J J Lynch; S A Thomas; M E Mills; K Malinow; A H Katcher
Journal:  J Nerv Ment Dis       Date:  1974-02       Impact factor: 2.254

10.  The physiological disposition of 14 C-methsuximide in the rat.

Authors:  P J Nicholls; T C Orton
Journal:  Br J Pharmacol       Date:  1972-05       Impact factor: 8.739
View more
  7 in total

Review 1.  Formation of active metabolites of psychotropic drugs. An updated review of their significance.

Authors:  S Caccia; S Garattini
Journal:  Clin Pharmacokinet       Date:  1990-06       Impact factor: 6.447

2.  Acebutolol in hypertension: relationships between drug concentration and effects.

Authors:  M A Martin; F C Phillips; G T Tucker; A J Smith
Journal:  Eur J Clin Pharmacol       Date:  1978-12-18       Impact factor: 2.953

3.  Effect of a diffusional barrier to a metabolite across hepatocytes on its kinetics in "enzyme-distributed" models: a computer-aided simulation study.

Authors:  S Miyauchi; Y Sugiyama; H Sato; Y Sawada; T Iga; M Hanano
Journal:  J Pharmacokinet Biopharm       Date:  1987-08

4.  The relationship between serum concentrations and central nervous system actions of metoprolol.

Authors:  F M Gengo; J C Ermer; C Carey; G C Kalonaros; W B McHugh
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-02       Impact factor: 10.154

Review 5.  A review of metabolite kinetics.

Authors:  K S Pang
Journal:  J Pharmacokinet Biopharm       Date:  1985-12

6.  Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man.

Authors:  P N Bennett; L J Aarons; M R Bending; J A Steiner; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1982-06

7.  Significance of acetylator phenotype in pharmacokinetics and adverse effects of procainamide.

Authors:  P Ylitalo; R Ruosteenoja; O Leskinen; T Metsä-Ketelä
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.