| Literature DB >> 32345464 |
Mohamed A Eldeeb1, Andrew N Bayne2, Jean-François Trempe2, Edward A Fon3.
Abstract
Given their polyvalent functions, an inherent challenge that mitochondria face is the exposure to mitochondrial import stresses, culminating in their dysfunction. Recently, mitochondrial import of several mitochondrial substrates was shown to be regulated via a 'tug of war' between USP30 and MARCH5, two ubiquitin-related enzymes located at the TOM complex.Entities:
Keywords: MARCH5; TOM complex; USP30; mitochondrial quality control; proteasome; protein degradation; protein quality control; ubiquitin
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Year: 2020 PMID： 32345464 DOI： 10.1016/j.tcb.2020.04.007
Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808