Meng-Hsing Wu1,2, Pei-Fang Su3, Wei-Ying Chu3, Chih-Wei Lin2, New Geok Huey2, Chung-Ying Lin4, Huang-Tz Ou5,6,7. 1. Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 2. Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan. 3. Department of Statistics, National Cheng Kung University, Tainan, Taiwan. 4. Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. 5. Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 6. Department of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 7. Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan.
Abstract
OBJECTIVE: We assessed the quality of life (QoL) and pregnancy outcomes of in vitro fertilization (IVF) treatment among infertile women with endometriosis, as compared to infertile women without endometriosis. STUDY DESIGN: Eighty-one (81) endometriosis women (with 142 embryo transfer [ET] cycles) and 605 non-endometriosis women (with 1063 ET cycles) were included. QoL was measured by FertiQoL at the date before ET. Pregnancy outcomes included biochemical pregnancy, ongoing pregnancy and live birth. Generalized estimating equation analyses were performed to assess the association between QoL and IVF pregnancy. RESULTS: Endometriosis-affected women had significantly lower QoL, as indicated by mind/body, treatment environment and total treatment scores, and total scores of FertiQoL (p < .05), compared to those without endometriosis. Among non-endometriosis women, QoL scores were significantly associated with successful IVF pregnancy; with one unit increase in QoL scores as measured by emotional domain of FertiQoL, the probabilities of ongoing pregnancy and live birth significantly increased by 2.5% and 2.8%, respectively (p < .05). This association was also observed among endometriosis women but it did not reach statistical significance. CONCLUSIONS: Lower QoL among women with endometriosis versus non-endometriosis during IVF treatment highlights the importance of developing strategies to improve their QoL, which may enhance following pregnancy rates in this population.
OBJECTIVE: We assessed the quality of life (QoL) and pregnancy outcomes of in vitro fertilization (IVF) treatment among infertile women with endometriosis, as compared to infertile women without endometriosis. STUDY DESIGN: Eighty-one (81) endometriosiswomen (with 142 embryo transfer [ET] cycles) and 605 non-endometriosiswomen (with 1063 ET cycles) were included. QoL was measured by FertiQoL at the date before ET. Pregnancy outcomes included biochemical pregnancy, ongoing pregnancy and live birth. Generalized estimating equation analyses were performed to assess the association between QoL and IVF pregnancy. RESULTS:Endometriosis-affected women had significantly lower QoL, as indicated by mind/body, treatment environment and total treatment scores, and total scores of FertiQoL (p < .05), compared to those without endometriosis. Among non-endometriosiswomen, QoL scores were significantly associated with successful IVF pregnancy; with one unit increase in QoL scores as measured by emotional domain of FertiQoL, the probabilities of ongoing pregnancy and live birth significantly increased by 2.5% and 2.8%, respectively (p < .05). This association was also observed among endometriosiswomen but it did not reach statistical significance. CONCLUSIONS: Lower QoL among women with endometriosis versus non-endometriosis during IVF treatment highlights the importance of developing strategies to improve their QoL, which may enhance following pregnancy rates in this population.
Entities:
Keywords:
Endometriosis; FertiQoL; in vitro fertilization; pregnancy; quality of life
Authors: Evdochia Adoamnei; Inés Morán-Sánchez; María Luisa Sánchez-Ferrer; Jaime Mendiola; María Teresa Prieto-Sánchez; Miriam Moñino-García; Joaquín A Palomar-Rodríguez; Alberto Manuel Torres-Cantero Journal: Int J Environ Res Public Health Date: 2021-05-24 Impact factor: 3.390