Literature DB >> 3234489

Nitric oxide release from the isolated guinea pig heart.

M Kelm1, J Schrader.   

Abstract

Nitric oxide (NO) release from isolated guinea pig hearts into the coronary effluent perfusate was measured with a specific spectrophotometric assay. Nitric oxide was continuously released under basal conditions at a rate of 216 +/- 36 pmol/min. Bradykinin (5 X 10(-10)-10(-8) M) stimulated the release of nitric oxide in a dose-dependent manner. The start of NO release preceded coronary vasodilation by 5 +/- 1 s. Our results suggest that the endogenous formation of nitric oxide is quantitatively sufficient to influence the coronary vascular tone and thus may play a significant role in the regulation of coronary vascular resistance.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3234489     DOI： 10.1016/0014-2999(88)90522-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  24 in total

Review 1.  Analytical chemistry of nitric oxide.

Authors:  Evan M Hetrick; Mark H Schoenfisch
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2009       Impact factor: 10.745

2.  On-line measurement of nitric oxide release from organic nitrates in the intact coronary circulation.

Authors:  K Schrör; S Förster; I Woditsch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-08       Impact factor: 3.000

3.  NG-nitro-L-arginine antagonizes endothelium-dependent dilator responses by inhibiting endothelium-derived relaxing factor release in the isolated rabbit heart.

Authors:  D Lamontagne; U Pohl; R Busse
Journal:  Pflugers Arch       Date:  1991-04       Impact factor: 3.657

4.  Mechanism of 5-hydroxytryptamine-induced coronary vasodilation assessed by direct detection of nitric oxide production in guinea-pig isolated heart.

Authors:  A J Ellwood; M J Curtis
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

5.  Comparison of relaxation responses of vascular and non-vascular smooth muscle to endothelium-derived relaxing factor (EDRF), acidified sodium nitrite (NO) and sodium nitroprusside.

Authors:  T M Cocks; J A Angus
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

6.  Deutsche Physiologische Gesellschaft. Abstracts of the 68th meeting (spring meeting). 6-9 March 1990, Heidelberg.

Authors: 
Journal:  Pflugers Arch       Date:  1990       Impact factor: 3.657

7.  Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiols.

Authors:  X Liu; J S Gillespie; W Martin
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

8.  Effects of nitric oxide synthase inhibitors, L-NG-nitroarginine and L-NG-nitroarginine methyl ester, on responses to vasodilators of the guinea-pig coronary vasculature.

Authors:  A Vials; G Burnstock
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

9.  Effects of bradykinin in the rat isolated perfused heart: role of kinin receptors and endothelium-derived relaxing factor.

Authors:  A R Baydoun; B Woodward
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

10.  L-arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cells.

Authors:  H H Schmidt; S E Baeblich; B C Zernikow; M M Klein; E Böhme
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.