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Correction: Etelcalcetide in Patients on Hemodialysis with Severe Secondary Hyperparathyroidism. Multicenter Study in "Real Life". J. Clin. Med. 2019, 8, 1066.

Domenico Russo1, Rocco Tripepi2, Fabio Malberti3, Biagio Di Iorio4, Bernadette Scognamiglio1, Luca Di Lullo5, Immacolata Gaia Paduano1, Giovanni Luigi Tripepi2, Vincenzo Antonio Panuccio6.   

Abstract

The authors wish to make the following corrections to the previous publication [...].

Entities:  

Year:  2020        PMID: 32344506      PMCID: PMC7230265          DOI: 10.3390/jcm9041224

Source DB:  PubMed          Journal:  J Clin Med        ISSN: 2077-0383            Impact factor:   4.241


The authors wish to make the following corrections to the previous publication [1] in the text, Table 1 and Table 2, and also Figure 1.
Table 1

Patients’ Characteristics.

Total Group(n = 168)Naïve Group(n = 56)Switch Group(n = 112)p(Naïve vs Switch)
Age (years)61 ± 1464 ± 1459 ± 140.04
Male (%)5752600.32
Dialysis vintage (month)58 (IQR 32–102)35 (IQR 14–63)69 (IQR 48–120)<0.001
Diabetes (%)2531220.23
Cardiovascular comorbidities (%)7370750.53
iPTH (pg/mL)636 (IQR 493–916)602 (IQR 509–800)664 (IQR 495–947)0.67
Serum Calcium (mEq/L)9.0 ± 1.09.1 ± 0.79.0 ± 1.10.60
Serum Phosphate (mg/dL)5.6 ± 1.45.5 ± 1.45.6 ± 1.40.83
Alkaline Phosphate (U.I./L)131 (IQR 83–201)111 (IQR 74–159)148 (IQR 88–221)0.02
Hb (gr/dL)11.1 ± 1.411.0 ± 1.211.1 ± 1.40.58
ESA treatment (%)8788870.97
Phosphate binders therapy (%)9693970.17
Calcium containing binders (%)1825140.09
Vitamin D therapy (%)7583710.09
Native Vitamin D therapy (%)5460.59
Previous cinacalcet treatment (%)670100N/A

IQR, interquartile range; iPTH, intact parathyroid hormone; Hb, hemoglobin; ESA, erythropoietin-stimulating agent.

Table 2

Cases of hypocalcemia.

Days after Parsabiv<7.0 mEq/L≥7.0 or <7.5 mEq/L≥7.5 or <8.3 mEq/L
303/168 (1.8%)025/168 (14.9%))
601/129 (0.8%)7/129 (5.4%)28/129 (21.7%)
902/111 (1.8%)2/111 (1.8%)27/111 (24.3%)
1201/80 (1.3%)1/80 (1.3%)21/80 (26.2%)
1501/61 (1.6%)6/61 (9.8%)11/61 (18.0%)
18001/44 (2.3%)11/44 (25.0%)
21001/51 (2.0%)15/51 (29.4%)
Figure 1

P for the trend of intact parathyroid hormone (iPTH) (panel a), serum calcium (panel b), serum phosphate (panel c), alkaline phosphatase (panel d) over time was obtained using linear regression models weighted for patients’ identification (see methods for more details).

In the text on page 2, it is reported that “The following levels of serum calcium were used for the definition of hypocalcemia: < 7.0 mEq/L; ≥ 7.0 but ≤ 7.5 mEq/L; ≥ 7.5 but < 8.3 mEq/L”. This statement needs to be corrected: “The following levels of serum calcium were used for the definition of hypocalcemia: < 7.0 mg/dL; ≥ 7.0 but ≤ 7.5 mg/dL; > 7.5 but < 8.3 mg/dL”. We wish to correct the caption of Table 1 where serum calcium concentrations are reported as mEq/L instead of mg/dL. The caption of the amended Table 1 is:
Table 1

Patients’ Characteristics.

Total Group(n = 168)Naïve Group(n = 56)Switch Group(n = 112)p(Naïve vs Switch)
Age (years)61 ± 1464 ± 1459 ± 140.04
Male (%)5752600.32
Dialysis vintage (month)58 (IQR 32–102)35 (IQR 14–63)69 (IQR 48–120)<0.001
Diabetes (%)2531220.23
Cardiovascular comorbidities (%)7370750.53
iPTH (pg/mL)636 (IQR 493–916)602 (IQR 509–800)664 (IQR 495–947)0.67
Serum Calcium (mg/dL)9.0 ± 1.09.1 ± 0.79.0 ± 1.10.60
Serum Phosphate (mg/dL)5.6 ± 1.45.5 ± 1.45.6 ± 1.40.83
Alkaline Phosphate (U.I./L)131 (IQR 83–201)111 (IQR 74–159)148 (IQR 88–221)0.02
Hb (gr/dL)11.1 ± 1.411.0 ± 1.211.1 ± 1.40.58
ESA treatment (%)8788870.97
Phosphate binders therapy (%)9693970.17
Calcium containing binders (%)1825140.09
Vitamin D therapy (%)7583710.09
Native Vitamin D therapy (%)5460.59
Previous cinacalcet treatment (%)670100N/A

IQR, interquartile range; iPTH, intact parathyroid hormone; Hb, hemoglobin; ESA, erythropoietin-stimulating agent.

We wish to correct the caption of Table 2 where serum calcium concentrations are reported as mEq/L instead of mg/dL and etelcalcetide is reported as Parsabiv (trade name). The caption of the amended Table 2 is:
Table 2

Cases of hypocalcemia.

Days after Etelcalcetide<7.0 mg/dL≥7.0 or ≤7.5 mg/dL>7.5 or <8.3 mg/dL
303/168 (1.8%)025/168 (14.9%))
601/129 (0.8%)7/129 (5.4%)28/129 (21.7%)
902/111 (1.8%)2/111 (1.8%)27/111 (24.3%)
1201/80 (1.3%)1/80 (1.3%)21/80 (26.2%)
1501/61 (1.6%)6/61 (9.8%)11/61 (18.0%)
18001/44 (2.3%)11/44 (25.0%)
21001/51 (2.0%)15/51 (29.4%)
We wish to correct the caption of Figure 1 where serum calcium concentrations are reported as mEq/L instead of mg/dL. The caption of the amended Figure 1 is:
Figure 1

P for the trend of intact parathyroid hormone (iPTH) (panel a), serum calcium (panel b), serum phosphate (panel c), alkaline phosphatase (panel d) over time was obtained using linear regression models weighted for patients’ identification (see methods for more details).

The authors apologize to the readers for any inconvenience caused by these changes. It is important to state that this correction does not affect our study’s results and involves no changes or modifications in the original data supporting our results. The original manuscript [1] will remain online on the article webpage, with reference to this Correction.
  1 in total

1.  Etelcalcetide in Patients on Hemodialysis with Severe Secondary Hyperparathyroidism. Multicenter Study in "Real Life".

Authors:  Domenico Russo; Rocco Tripepi; Fabio Malberti; Biagio Di Iorio; Bernadette Scognamiglio; Luca Di Lullo; Immacolata Gaia Paduano; Giovanni Luigi Tripepi; Vincenzo Antonio Panuccio
Journal:  J Clin Med       Date:  2019-07-20       Impact factor: 4.241

  1 in total
  1 in total

1.  Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide.

Authors:  Guillaume Dachy; Jean-Michel Pochet; Laura Labriola; Antoine Buemi; Valentine Gillion; Michel Jadoul; Nada Kanaan; Arnaud Devresse
Journal:  Clin Kidney J       Date:  2021-03-17
  1 in total

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